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Literature DB >> 12032596

A novel human gene whose product shares homology with bovine brain-specific protein p25 is expressed in fetal brain but not in adult brain.

Zhen Zhang¹, ChaoQun Wu, Wei Huang, Shu Wang, EnPeng Zhao, QingShan Huang, Yi Xie, YuMin Mao.

Abstract

We have cloned a novel human gene ( C14orf5) from a fetal brain cDNA library that is located on chromosome 14 and consists of 4 exons. It encodes a protein of 170 amino acids that shares homology with human p25 alpha and bovine p25. Reverse transcription-polymerase chain reaction analysis indicated that it is highly expressed in liver and pancreas. Its transcripts could not be detected in adult brain but could be found in fetal brain.

Entities: Gene Species

Mesh：

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Year: 2002 PMID： 12032596 DOI： 10.1007/s100380200037

Source DB: PubMed Journal: J Hum Genet ISSN： 1434-5161 Impact factor: 3.172

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Cited

7 in total

1. p25alpha is flexible but natively folded and binds tubulin with oligomeric stoichiometry.

Authors: Daniel E Otzen; Ditte M S Lundvig; Reinhard Wimmer; Lotte H Nielsen; Jakob R Pedersen; Poul H Jensen
Journal: Protein Sci Date: 2005-05-09 Impact factor: 6.725

2. Whole-exome sequencing in maya indigenous families: variant in PPP1R3A is associated with type 2 diabetes.

Authors: Katy Sánchez-Pozos; María Guadalupe Ortíz-López; Bárbara I Peña-Espinoza; María de Los Ángeles Granados-Silvestre; Verónica Jiménez-Jacinto; Jérôme Verleyen; Fasil Tekola-Ayele; Alejandro Sanchez-Flores; Marta Menjivar
Journal: Mol Genet Genomics Date: 2018-06-11 Impact factor: 3.291

A novel human gene whose product shares homology with bovine brain-specific protein p25 is expressed in fetal brain but not in adult brain.

1. p25alpha is flexible but natively folded and binds tubulin with oligomeric stoichiometry.

2. Whole-exome sequencing in maya indigenous families: variant in PPP1R3A is associated with type 2 diabetes.

3. Stable knockdown of TPPP3 by RNA interference in Lewis lung carcinoma cell inhibits tumor growth and metastasis.

4. A fish-specific member of the TPPP protein family?

5. Depletion of tubulin polymerization promoting protein family member 3 suppresses HeLa cell proliferation.

6. TPPP/p25 promotes tubulin assemblies and blocks mitotic spindle formation.

Review 7. Microtubule-Associated Proteins with Regulatory Functions by Day and Pathological Potency at Night.