Literature DB >> 1203221

Early breakdown of the blood-retinal barrier in diabetes.

J Cunha-Vaz, J R Faria de Abreu, A J Campos.   

Abstract

The blood-retinal barrier plays an important part in the processes of retinal pathophysiology. A new clinical method for the study of the blood-retinal barrier by vitreous fluorophotometry appears to satisfy the necessary requirements in that it is quantitative and shows good reproducibility and high sensitivity. The application of this method to a series of diabetic patients with apparently "normal" fundi revealed the presence of a significant breakdown of the blood-retinal barrier in the early stages of retinal involvement in diabetes. The extent of the breakdown can be measured allowing for comparative and evolutionary evaluations. The disturbance of the blood-retinal barrier, as evidence by vitreous fluorophotometry, appears before microaneurysms or capillary closure can be demonstrated by fluorescein angiography.

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Year:  1975        PMID： 1203221      PMCID： PMC1017427          DOI： 10.1136/bjo.59.11.649

Source DB:  PubMed          Journal:  Br J Ophthalmol        ISSN： 0007-1161            Impact factor:   4.638


  4 in total

1.  Fluorophotometric recording of fluorescein dilution curves in human retinal vessels.

Authors:  I Ben-Sira; C E Riva
Journal:  Invest Ophthalmol       Date:  1973-04

2.  The active transport of fluorescein by the retinal vessels and the retina.

Authors:  J G Cunha-Vaz; D M Maurice
Journal:  J Physiol       Date:  1967-08       Impact factor: 5.182

3.  A new objective slit lamp fluorophotometer.

Authors:  S R Waltman; H E Kaufman
Journal:  Invest Ophthalmol       Date:  1970-04

4.  Bowman lecture. The blood-retinal barrier and vaso-glial relationships in retinal disease.

Authors:  N Ashton
Journal:  Trans Ophthalmol Soc U K       Date:  1965
  4 in total
  134 in total

1.  Penetration of topical, oral, and combined administered ofloxacin into the subretinal fluid.

Authors:  O Cekiç; C Batman; U Yasar; Y Totan; N E Basci; A Bozkurt; O Zilelioglu; S O Kayaalp
Journal:  Br J Ophthalmol       Date:  1999-10       Impact factor: 4.638

Review 2.  Macular oedema: the role of soluble mediators.

Authors:  D Kent; S A Vinores; P A Campochiaro
Journal:  Br J Ophthalmol       Date:  2000-05       Impact factor: 4.638

3.  Editorial: Fluorescein and diabetes.

Authors: 
Journal:  Br J Ophthalmol       Date:  1975-11       Impact factor: 4.638

4.  New approaches to ophthalmic electrodiagnosis by retinal oscillatory potential, drug-induced responses from retinal pigment epithelium and cone potential.

Authors:  D Yonemura; K Kawasaki
Journal:  Doc Ophthalmol       Date:  1979-12-14       Impact factor: 2.379

5.  Sympathetic mediated vasomotion and skin capillary permeability in diabetic patients with peripheral neuropathy.

Authors:  J D Lefrandt; E Bosma; P H N Oomen; J H Hoeven; A M Roon; A J Smit; K Hoogenberg
Journal:  Diabetologia       Date:  2003-01-11       Impact factor: 10.122

6.  Relationship between perifoveal capillaries and pathomorphology in macular oedema associated with branch retinal vein occlusion.

Authors:  T Murakami; A Tsujikawa; K Miyamoto; A Sakamoto; M Ota; K Ogino; N Yoshimura
Journal:  Eye (Lond)       Date:  2012-06-01       Impact factor: 3.775

7.  Vitreous fluorophotometric recordings in HIV infection.

Authors:  M Cellini; A Baldi
Journal:  Int Ophthalmol       Date:  1991-01       Impact factor: 2.031

8.  Aralia elata inhibits neurodegeneration by downregulating O-GlcNAcylation of NF-κB in diabetic mice.

Authors:  Seong-Jae Kim; Min-Jun Kim; Mee-Young Choi; Yoon-Sook Kim; Ji-Myong Yoo; Eun-Kyung Hong; Sunmi Ju; Wan-Sung Choi
Journal:  Int J Ophthalmol       Date:  2017-08-18       Impact factor: 1.779

9.  Studies of retinopathy and the plasma co-factor of platelet hyperaggregation in type 1 (insulin-dependent) diabetic children.

Authors:  R D Levin; H C Kwaan; J G Dobbie; C L Fetkenhour; H S Traisman; C Kramer
Journal:  Diabetologia       Date:  1982-06       Impact factor: 10.122

10.  Presence and further development of retinal dysfunction after 3-year follow up in IDDM patients without angiographically documented vasculopathy.

Authors:  M A Di Leo; S Caputo; B Falsini; V Porciatti; A V Greco; G Ghirlanda
Journal:  Diabetologia       Date:  1994-09       Impact factor: 10.122
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