Literature DB >> 12031449

Inhibition of alpha-glucosidase by oleanolic acid and its synthetic derivatives.

Muhammad Shaiq Ali1, Muhammad Jahangir, Syed Shazad ul Hussan, Muhammad Iqbal Choudhary.   

Abstract

Oleanolic acid (1) and five synthetic derivatives (2-6) were tested spectrophotometrically for inhibition of urease, beta-lactamase, acetyl cholinesterase and alpha-glucosidase. All products showed a positive response only against alpha-glucosidase but not against the other enzymes; IC(50) calculations showed that the dihydroxy-olide derivative (4) was the most potent among all tested samples.

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Year:  2002        PMID： 12031449     DOI： 10.1016/s0031-9422(02)00104-8

Source DB:  PubMed          Journal:  Phytochemistry        ISSN： 0031-9422            Impact factor:   4.072


  16 in total

1.  Efficient oxidation of oleanolic acid derivatives using magnesium bis(monoperoxyphthalate) hexahydrate (MMPP): A convenient 2-step procedure towards 12-oxo-28-carboxylic acid derivatives.

Authors:  Jorge A R Salvador; Vânia M Moreira; Rui M A Pinto; Ana S Leal; José A Paixão
Journal:  Beilstein J Org Chem       Date:  2012-01-30       Impact factor: 2.883

Review 2.  Recent advances in synthesis and biological activity of triterpenic acylated oximes.

Authors:  Barbara Bednarczyk-Cwynar; Lucjusz Zaprutko
Journal:  Phytochem Rev       Date:  2014-04-11       Impact factor: 5.374

3.  Antidiabetic property of Symplocos cochinchinensis is mediated by inhibition of alpha glucosidase and enhanced insulin sensitivity.

Authors:  Kalathookunnel Antony Antu; Mariam Philip Riya; Arvind Mishra; Karunakaran S Anilkumar; Chandrasekharan K Chandrakanth; Akhilesh K Tamrakar; Arvind K Srivastava; K Gopalan Raghu
Journal:  PLoS One       Date:  2014-09-03       Impact factor: 3.240

4.  Synthesis of acyl oleanolic acid-uracil conjugates and their anti-tumor activity.

Authors:  Wei-Bin Mo; Chun-Hua Su; Jia-Yan Huang; Jun Liu; Zhen-Feng Chen; Ke-Guang Cheng
Journal:  Chem Cent J       Date:  2016-11-21       Impact factor: 4.215

Review 5.  Bioautography and its scope in the field of natural product chemistry.

Authors:  Saikat Dewanjee; Moumita Gangopadhyay; Niloy Bhattacharya; Ritu Khanra; Tarun K Dua
Journal:  J Pharm Anal       Date:  2014-06-26

6.  Oleanolic acid: a novel cardioprotective agent that blunts hyperglycemia-induced contractile dysfunction.

Authors:  Rudo F Mapanga; Uthra Rajamani; Nonkululeko Dlamini; Makhosazane Zungu-Edmondson; Roisin Kelly-Laubscher; Mohammed Shafiullah; Athiq Wahab; Mohamed Y Hasan; Mohamed A Fahim; Philippe Rondeau; Emmanuel Bourdon; M Faadiel Essop
Journal:  PLoS One       Date:  2012-10-16       Impact factor: 3.240

Review 7.  Biochemical basis of the antidiabetic activity of oleanolic acid and related pentacyclic triterpenes.

Authors:  Jose M Castellano; Angeles Guinda; Teresa Delgado; Mirela Rada; Jose A Cayuela
Journal:  Diabetes       Date:  2013-06       Impact factor: 9.461

Review 8.  The role of triterpenes in the management of diabetes mellitus and its complications.

Authors:  J Nazaruk; M Borzym-Kluczyk
Journal:  Phytochem Rev       Date:  2014-06-24       Impact factor: 5.374

9.  Self-microemulsifying drug delivery system for improved oral bioavailability of oleanolic acid: design and evaluation.

Authors:  Rui Yang; Xin Huang; Jinfeng Dou; Guangxi Zhai; Lequn Su
Journal:  Int J Nanomedicine       Date:  2013-08-08

10.  In vitro α-amylase and α-glucosidase inhibitory effects and cytotoxic activity of Albizia antunesiana extracts.

Authors:  Talent Chipiti; Mohammed Auwal Ibrahim; Moganavelli Singh; Md Shahidul Islam
Journal:  Pharmacogn Mag       Date:  2015-10       Impact factor: 1.085
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