| Literature DB >> 12031328 |
Ginger X Yang1, Linda L Chang, Quang Truong, George A Doherty, Plato A Magriotis, Stephen E de Laszlo, Bing Li, Malcolm MacCoss, Usha Kidambi, Linda A Egger, Ermengilda McCauley, Gail Van Riper, Richard A Mumford, John A Schmidt, William K Hagmann.
Abstract
Given the proposed involvement of VLA-4 in inflammatory processes, a program to identify orally active VLA-4 antagonists was initiated. Herein, we report the discovery of a N-tetrahydrofuroyl-(L)-phenylalanine derivative (17) and related analogues as potent VLA-4 antagonists with good oral bioavailability.Entities:
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Year: 2002 PMID： 12031328 DOI： 10.1016/s0960-894x(02)00210-x
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823