| Literature DB >> 12031324 |
Irene Drizin1, Mark W Holladay, Lin Yi, Henry Q Zhang, Sujatha Gopalakrishnan, Murali Gopalakrishnan, Kristi L Whiteaker, Steven A Buckner, James P Sullivan, William A Carroll.
Abstract
A novel series of tricyclic dihydropyrimidines was synthesized and evaluated for activity as K(ATP) channel openers. The functional activity of several compounds, for example 6A (EC(50)=30nM) and its enantiomers exceeded cromakalim.Entities:
Mesh：
Substances：
Year: 2002 PMID： 12031324 DOI： 10.1016/s0960-894x(02)00207-x
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823