Conservative treatment of malignant (invasive) external otitis caused by Aspergillus flavus with oral itraconazole solution in a neutropenic patient.

Aspergillus flavus causes invasive external otitis associated with severe infection of the skull base. A combination of amphotericin B, surgical debridement and long-term itraconazole is considered the therapy of choice. We report a case of invasive external otitis due to A. flavus that was treated successfully with a short course of amphotericin B and long-term oral itraconazole without surgical intervention.