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Literature DB >> 12030279

Glucocorticoids in adipocytes stimulate visceral obesity.

Abstract

The enzyme 11beta hydroxysteroid dehydrogenase-1 (11beta HSD-1) regenerates active glucocorticoids from inactive glucocorticoids. When over-expressed in adipose tissue, this enzyme was shown to promote increased visceral adipose levels. The resulting visceral obesity was associated with insulin-resistant diabetes and dyslipidemia. Increased adipocyte 11beta HSD-1 is a possible cause of visceral obesity in humans.

Entities: Disease Gene Species

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Year: 2002 PMID： 12030279 DOI： 10.1301/00296640260093823

Source DB: PubMed Journal: Nutr Rev ISSN： 0029-6643 Impact factor: 7.110

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Cited

9 in total

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Review 2. Drug-induced obesity and its metabolic consequences: a review with a focus on mechanisms and possible therapeutic options.

Authors: A A Verhaegen; L F Van Gaal
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3. Endocrine and physiological changes in response to chronic corticosterone: a potential model of the metabolic syndrome in mouse.

Authors: Ilia N Karatsoreos; Sarah M Bhagat; Nicole P Bowles; Zachary M Weil; Donald W Pfaff; Bruce S McEwen
Journal: Endocrinology Date: 2010-03-08 Impact factor: 4.736

4. 11β-Hydroxysteroid dehydrogenase type-2 and type-1 (11β-HSD2 and 11β-HSD1) and 5β-reductase activities in the pathogenia of essential hypertension.

Authors: Carmen Campino; Cristian A Carvajal; Javiera Cornejo; Betty San Martín; Oliviero Olivieri; Giancesare Guidi; Giovanni Faccini; Francesco Pasini; Javiera Sateler; Rene Baudrand; Lorena Mosso; Gareth I Owen; Alexis M Kalergis; Oslando Padilla; Carlos E Fardella
Journal: Endocrine Date: 2009-10-31 Impact factor: 3.633

5. Overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in hepatic and visceral adipose tissue is associated with metabolic disorders in morbidly obese patients.

Authors: René Baudrand; Cristian A Carvajal; Arnoldo Riquelme; Mauricio Morales; Nancy Solis; Margarita Pizarro; Alex Escalona; Camilo Boza; Gustavo Pérez; Angélica Domínguez; Marco Arrese; Carlos E Fardella
Journal: Obes Surg Date: 2009-08-19 Impact factor: 4.129

Glucocorticoids in adipocytes stimulate visceral obesity.

Review 1. Drugs Affecting Body Weight, Body Fat Distribution, and Metabolic Function-Mechanisms and Possible Therapeutic or Preventive Measures: an Update.

Review 2. Drug-induced obesity and its metabolic consequences: a review with a focus on mechanisms and possible therapeutic options.

3. Endocrine and physiological changes in response to chronic corticosterone: a potential model of the metabolic syndrome in mouse.

4. 11β-Hydroxysteroid dehydrogenase type-2 and type-1 (11β-HSD2 and 11β-HSD1) and 5β-reductase activities in the pathogenia of essential hypertension.

5. Overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in hepatic and visceral adipose tissue is associated with metabolic disorders in morbidly obese patients.

6. Anatomic, hematologic, and biochemical features of C57BL/6NCrl mice maintained on chronic oral corticosterone.

7. Do the interactions between glucocorticoids and sex hormones regulate the development of the metabolic syndrome?

Review 8. Asthma and risk of cardiovascular disease or all-cause mortality: a meta-analysis.

9. Modulation in Wistar rats of blood corticosterone compartmentation by sex and a cafeteria diet.