AIMS: To provide evidence of water quality as a risk factor for acquisition of Helicobacter pylori in early life, and to identify evidence for its presence within pots used to store drinking water. METHODS AND RESULTS: A prospective cohort study of 65 infants was conducted in the rural village of Keneba, The Gambia. Age of H. pylori colonization was determined and water pot biofilms were tested for H. pylori by sequencing of amplified DNA. Use of supplemental water was a strong risk factor for H. pylori colonization in infants (OR 4.71, 95% CI 1.17-22.5). DNA with 95% homology to the 16S rRNA gene of H. pylori was isolated from biofilms of water pots. CONCLUSIONS: Drinking water may be a reservoir for H. pylori in areas of the developing world where water quality is poor. Early introduction of water, particularly if stored in, or collected from contaminated sources, may be associated with an increased rate of H. pylori colonization.
AIMS: To provide evidence of water quality as a risk factor for acquisition of Helicobacter pylori in early life, and to identify evidence for its presence within pots used to store drinking water. METHODS AND RESULTS: A prospective cohort study of 65 infants was conducted in the rural village of Keneba, The Gambia. Age of H. pylori colonization was determined and water pot biofilms were tested for H. pylori by sequencing of amplified DNA. Use of supplemental water was a strong risk factor for H. pylori colonization in infants (OR 4.71, 95% CI 1.17-22.5). DNA with 95% homology to the 16S rRNA gene of H. pylori was isolated from biofilms of water pots. CONCLUSIONS:Drinking water may be a reservoir for H. pylori in areas of the developing world where water quality is poor. Early introduction of water, particularly if stored in, or collected from contaminated sources, may be associated with an increased rate of H. pylori colonization.
Authors: Crystal L Richards; Brittany J Buchholz; Timothy E Ford; Susan C Broadaway; Barry H Pyle; Anne K Camper Journal: J Microbiol Methods Date: 2010-12-01 Impact factor: 2.363
Authors: Wayne Delport; Michael Cunningham; Brenda Olivier; Oliver Preisig; Schalk W van der Merwe Journal: Genetics Date: 2006-10-22 Impact factor: 4.562
Authors: Phabiola M Herrera; Melissa Mendez; Billie Velapatiño; Billie Velapatiõ; Livia Santivañez; Livia Santivaez; Jacqueline Balqui; S Alison Finger; Jonathan Sherman; Mirko Zimic; Lilia Cabrera; Jose Watanabe; Carlos Rodríguez; Robert H Gilman; Douglas E Berg Journal: J Clin Microbiol Date: 2008-10-08 Impact factor: 5.948