Literature DB >> 12028033

FGFR3 dysregulation in multiple myeloma: frequency and prognostic relevance.

Thomas Rasmussen1, Heidi Rye Hudlebusch, Lene Meldgaard Knudsen, Hans Erik Johnsen.   

Abstract

The t(4:14) translocation affects two potential oncogenes, FGFR3 and MMSET, in multiple myeloma (MM). We investigated the frequency of FGFR3 dysregulation and its prognostic value in MM. FGFR3 mRNA levels were determined in 110 diagnostic bone marrow (BM) samples from MM patients. In addition, selected BM samples were screened for elevated MMSET mRNA levels. 14.5% (16/110) of MM BM samples showed dysregulated FGFR3 expression. Follow-up of 76 MM patients showed no significant difference between FGFR3 dysfunction and survival (P = 0.3) or correlation with known prognostic factors. Further, no linear relation was observed between FGFR3 and MMSET levels.

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Year:  2002        PMID： 12028033     DOI： 10.1046/j.1365-2141.2002.03429.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  5 in total

1.  Genome wide transcriptional profiling in breast cancer cells reveals distinct changes in hormone receptor target genes and chromatin modifying enzymes after proteasome inhibition.

Authors:  H Karimi Kinyamu; Jennifer B Collins; Sherry F Grissom; Pratibha B Hebbar; Trevor K Archer
Journal:  Mol Carcinog       Date:  2008-11       Impact factor: 4.784

Review 2.  From the bench to the bedside: emerging new treatments in multiple myeloma.

Authors:  Constantine S Mitsiades; Patrick J Hayden; Kenneth C Anderson; Paul G Richardson
Journal:  Best Pract Res Clin Haematol       Date:  2007-12       Impact factor: 3.020

Review 3.  Survival and proliferation factors of normal and malignant plasma cells.

Authors:  Bernard Klein; Karin Tarte; Michel Jourdan; Karene Mathouk; Jerome Moreaux; Eric Jourdan; Eric Legouffe; John De Vos; Jean François Rossi
Journal:  Int J Hematol       Date:  2003-08       Impact factor: 2.490

Review 4.  Association of Chromosomal Translocation and MiRNA Expression with The Pathogenesis of Multiple Myeloma.

Authors:  Najmaldin Saki; Saeid Abroun; Saeideh Hajizamani; Fakher Rahim; Mohammad Shahjahani
Journal:  Cell J       Date:  2014-05-25       Impact factor: 2.479

5.  FGF signaling inhibits the proliferation of human myeloma cells and reduces c-myc expression.

Authors:  Louise Firme; Andrew B Bush
Journal:  BMC Cell Biol       Date:  2003-12-04       Impact factor: 4.241
  5 in total

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