Literature DB >> 12027749

Isolation of streptonigrin and its novel derivative from Micromonospora as inducing agents of p53-dependent cell apoptosis.

Haishan Wang1, Su Ling Yeo, Jin Xu, Xiaoli Xu, Hong He, Francesca Ronca, Anthony E Ting, Yue Wang, Victor C Yu, Mui Mui Sim.   

Abstract

Streptonigrin (1) and its novel natural derivative 7-(1-methyl-2-oxopropyl)streptonigrin (2) were isolated from an actinomycete strain, Micromonospora sp. IM 2670. The inductions for 1 and 2 are more potent in the human neuroblastoma SH-SY5Y cells that contain wild-type p53 than in SH-SY5Y-5.6 cells that overexpress a dominant negative mutant of p53, thus suggesting that they induce apoptosis through a p53-dependent pathway.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 12027749     DOI： 10.1021/np0104572

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  5 in total

Review 1.  The genus Micromonospora as a model microorganism for bioactive natural product discovery.

Authors:  Mohamed S Hifnawy; Mohamed M Fouda; Ahmed M Sayed; Rabab Mohammed; Hossam M Hassan; Sameh F AbouZid; Mostafa E Rateb; Alexander Keller; Martina Adamek; Nadine Ziemert; Usama Ramadan Abdelmohsen
Journal:  RSC Adv       Date:  2020-06-08       Impact factor: 4.036

2.  Non-junctional Cx32 mediates anti-apoptotic and pro-tumor effects via epidermal growth factor receptor in human cervical cancer cells.

Authors:  Yifan Zhao; Yongchang Lai; Hui Ge; Yunquan Guo; Xue Feng; Jia Song; Qin Wang; Lixia Fan; Yuexia Peng; Minghui Cao; Andrew L Harris; Xiyan Wang; Liang Tao
Journal:  Cell Death Dis       Date:  2017-05-11       Impact factor: 8.469

3.  Diketopiperazine derivatives from the marine-derived actinomycete Streptomyces sp. FXJ7.328.

Authors:  Pei Wang; Lijun Xi; Peipei Liu; Yi Wang; Wei Wang; Ying Huang; Weiming Zhu
Journal:  Mar Drugs       Date:  2013-03-28       Impact factor: 5.118

4.  Total synthesis of the antitumor antibiotic (±)-streptonigrin: first- and second-generation routes for de novo pyridine formation using ring-closing metathesis.

Authors:  Timothy J Donohoe; Christopher R Jones; Anne F Kornahrens; Luiz C A Barbosa; Louise J Walport; Matthew R Tatton; Michael O'Hagan; Akshat H Rathi; David B Baker
Journal:  J Org Chem       Date:  2013-12-12       Impact factor: 4.354

5.  Identification of (2S,3S)-β-Methyltryptophan as the Real Biosynthetic Intermediate of Antitumor Agent Streptonigrin.

Authors:  Dekun Kong; Yi Zou; Zhang Zhang; Fei Xu; Nelson L Brock; Liping Zhang; Zixin Deng; Shuangjun Lin
Journal:  Sci Rep       Date:  2016-02-05       Impact factor: 4.379
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.