| Literature DB >> 12027658 |
Jacqueline H Smitrovich1, Geneviève N Boice, Chuanxing Qu, Lisa DiMichele, Todd D Nelson, Mark A Huffman, Jerry Murry, James McNamara, Paul J Reider.
Abstract
[reaction: see text] The asymmetric Michael reaction of pseudoephedrine amides is reported. The 1,5-dicarbonyl products are converted to 3-aryl-delta-lactones in a two-step reduction/lactonization sequence. This method provides access to enantiomerically enriched trans-3,4-disubstituted delta-lactones.Entities:
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Year: 2002 PMID： 12027658 DOI： 10.1021/ol0259847
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005