Literature DB >> 1202570

Effect of DEAE-dextran on protein synthesis in HeLa cells.

J L Saborio, K J Wiegers, G Koch.   

Abstract

Concentrations of DEAE-dextran which are currently used to stimulate the interaction between animal cells and natural or synthetic polynucleotides, inhibit protein synthesis in HeLa cells. This inhibition results from the blocking of more than one of the steps in protein synthesis, including transport of amino acids. The results support the hypothesis that enhancement of cellular competence for infection by viral RNA involves interference with initiation of cellular protein synthesis.

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Year:  1975        PMID： 1202570     DOI： 10.1007/bf02175599

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  17 in total

1.  Inhibition of initiation of protein synthesis in mammalian tissue culture cells by L-1-tosylamido-2-phenylethyl chloromethyl ketone.

Authors:  S S Pong; D L Nuss; G Koch
Journal:  J Biol Chem       Date:  1975-01-10       Impact factor: 5.157

2.  Selective blockage of initiation of host protein synthesis in RNA-virus-infected cells.

Authors:  D L Nuss; H Oppermann; G Koch
Journal:  Proc Natl Acad Sci U S A       Date:  1975-04       Impact factor: 11.205

Review 3.  Interaction of poliovirus-specific RNAs with HeLa cells and E. coli.

Authors:  G Koch
Journal:  Curr Top Microbiol Immunol       Date:  1973       Impact factor: 4.291

4.  Complex formation between poliovirus RNA and polycations.

Authors:  D Havliza; G Koch
Journal:  Arch Biochem Biophys       Date:  1971-11       Impact factor: 4.013

5.  Reversible inhibition of macromolecular synthesis in HeLa cells by ethanol.

Authors:  F Koch; G Koch
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1974-10

6.  Observations on the assay of infectious viral ribonucleic acid: effects of DMSO and DEAE-dextran.

Authors:  D R Tovell; J S Colter
Journal:  Virology       Date:  1967-05       Impact factor: 3.616

7.  Interferon messenger RNA: translation in heterologous cells.

Authors:  J de Maeyer-Guignard; E de Maeyer; L Montagnier
Journal:  Proc Natl Acad Sci U S A       Date:  1972-05       Impact factor: 11.205

8.  Control of interferon synthesis: effect of diethylaminoethyl-dextran on induction by polyinosinic-polycytidylic acid.

Authors:  J Vilcek; S L Barmak; E A Havell
Journal:  J Virol       Date:  1972-10       Impact factor: 5.103

9.  Influence of polycations on the interaction between poliovirus multistranded ribonucleic acid and HeLa cells.

Authors:  P Wentzky; G Koch
Journal:  J Virol       Date:  1971-07       Impact factor: 5.103

10.  The specificity of interferon induction in chick embryo cells by helical RNA.

Authors:  C Colby; M J Chamberlin
Journal:  Proc Natl Acad Sci U S A       Date:  1969-05       Impact factor: 11.205
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