| Literature DB >> 12023870 |
I Leclerc1, B Viollet, G da Silva Xavier, A Kahn, G A Rutter.
Abstract
AMP-activated protein kinase (AMPK) is a regulator of cellular metabolism in response to changes in the energy status of the cells. AMPK was known to shut down energy-consuming pathways in response to a fall in the ATP/AMP ratio by phosphorylating key enzymes of intermediate metabolism. Here we will discuss the recent evidence implicating AMPK in the regulation of gene expression in mammals, mainly in the liver and in the pancreatic beta-cells.Entities:
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Year: 2002 PMID： 12023870 DOI： 10.1042/
Source DB: PubMed Journal: Biochem Soc Trans ISSN： 0300-5127 Impact factor: 5.407