Literature DB >> 12023833

Proteinases in chronic obstructive pulmonary disease.

S D Shapiro1.   

Abstract

Chronic obstructive pulmonary disease (COPD) is a major health problem worldwide, and we have little specific therapy to offer these patients. One potential strategy to limit loss of lung function in COPD would be to inhibit matrix-degrading proteinases. Several serine proteinases and matrix metalloproteinases are expressed in association with COPD in humans. Application of gene-targeted macrophage elastase and neutrophil elastase to a mouse model of cigarette-smoke-induced emphysema has uncovered roles for these proteinases in airspace enlargement, and has identified many interactions between these proteolytic systems.

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Year:  2002        PMID： 12023833     DOI： 10.1042/

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  53 in total

Review 1.  Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases.

Authors:  Brice Korkmaz; Marshall S Horwitz; Dieter E Jenne; Francis Gauthier
Journal:  Pharmacol Rev       Date:  2010-12       Impact factor: 25.468

2.  Emphysema in COPD: consequences and causes.

Authors:  G M Turino
Journal:  Thorax       Date:  2006-12       Impact factor: 9.139

3.  Mechanical and failure properties of extracellular matrix sheets as a function of structural protein composition.

Authors:  Lauren D Black; Philip G Allen; Shirley M Morris; Phillip J Stone; Béla Suki
Journal:  Biophys J       Date:  2007-11-09       Impact factor: 4.033

4.  Cigarette smoke-induced emphysema in A/J mice is associated with pulmonary oxidative stress, apoptosis of lung cells, and global alterations in gene expression.

Authors:  Tirumalai Rangasamy; Vikas Misra; Lijie Zhen; Clarke G Tankersley; Rubin M Tuder; Shyam Biswal
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2009-03-13       Impact factor: 5.464

5.  Neutrophil elastase contributes to the pathological vascular permeability characteristic of diabetic retinopathy.

Authors:  Haitao Liu; Emma M Lessieur; Aicha Saadane; Sarah I Lindstrom; Patricia R Taylor; Timothy S Kern
Journal:  Diabetologia       Date:  2019-10-14       Impact factor: 10.122

Review 6.  Matrix metalloproteinases in emphysema.

Authors:  Sina A Gharib; Anne M Manicone; William C Parks
Journal:  Matrix Biol       Date:  2018-03-23       Impact factor: 11.583

7.  Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice.

Authors:  Jeffrey E Gotts; Lauren Chun; Jason Abbott; Xiaohui Fang; Naoki Takasaka; Stephen L Nishimura; Matthew L Springer; Suzaynn F Schick; Carolyn S Calfee; Michael A Matthay
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2018-03-15       Impact factor: 5.464

8.  Double deficiency of tetraspanins CD9 and CD81 alters cell motility and protease production of macrophages and causes chronic obstructive pulmonary disease-like phenotype in mice.

Authors:  Yoshito Takeda; Ping He; Isao Tachibana; Bo Zhou; Kenji Miyado; Hideshi Kaneko; Mayumi Suzuki; Seigo Minami; Takeo Iwasaki; Sho Goya; Takashi Kijima; Toru Kumagai; Mitsuhiro Yoshida; Tadashi Osaki; Toshihisa Komori; Eisuke Mekada; Ichiro Kawase
Journal:  J Biol Chem       Date:  2008-07-28       Impact factor: 5.157

Review 9.  Influencing the decline of lung function in COPD: use of pharmacotherapy.

Authors:  Ekaterina S Gladysheva; Atul Malhotra; Robert L Owens
Journal:  Int J Chron Obstruct Pulmon Dis       Date:  2010-06-03

Review 10.  Potential role of stem cells in management of COPD.

Authors:  Tillie L Hackett; Darryl A Knight; Don D Sin
Journal:  Int J Chron Obstruct Pulmon Dis       Date:  2010-04-07
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