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Literature DB >> 1202364

Effects of reserpine and propranolol on anoxia-induced enzyme release from the isolated perfused guinea-pig-heart.

Abstract

The possibility of a protective effect by reserpine or propranolol on anoxia-induced released of malate and lactate dehydrogenase was investigated in isolated perfused hearts of guinea-pigs. After allowing 30 min of aerobic perfusion for the development of a steady state, the hearts from the nontreated group as well as the reserpine-pretreated or propranolol-treated group were subjected to a prolonged anoxia of 5 hrs. A marked enzyme release which occurred from the anoxic nontreated hearts was significantly inhibited by reserpine or propranolol. These findings suggest that the enzyme release from the anoxic myocardium is partly related to the liberation of endogenous catecholamines.

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Year: 1975 PMID： 1202364 DOI： 10.1007/bf00500044

Source DB: PubMed Journal: Naunyn Schmiedebergs Arch Pharmacol ISSN： 0028-1298 Impact factor: 3.000

13 in total

1. Enzyme release resulting from total ischemia and reperfusion in the isolated, perfused guinea pig heart.

Authors: K Sakai; M M Gebhard; P G Spieckermann; H J Bretschneider
Journal: J Mol Cell Cardiol Date: 1975-11 Impact factor: 5.000

2. EVIDENCE FOR DIFFERENT SITES OF ACTION OF RESERPINE AND GUANETHIDINE.

Authors: A J MUSKUS
Journal: Naunyn Schmiedebergs Arch Exp Pathol Pharmakol Date: 1964-08-19

3. Muscle membrane as a dynamic structure and its permeability to aldolase.

Authors: K L ZIERLER
Journal: Ann N Y Acad Sci Date: 1958-10-13 Impact factor: 5.691

4. Abrupt reoxygenation of the anoxic potassium-arrested perfused rat heart: a study of myocardial enzyme release.

Authors: D J Hearse; S M Humphrey; E B Chain
Journal: J Mol Cell Cardiol Date: 1973-08 Impact factor: 5.000

5. A comparison of the local anaesthetic-, "quinidine-like"- and adrenergic beta-blocking-activities of five beta-receptor antagonists.

Authors: W G Davis
Journal: J Pharm Pharmacol Date: 1970-04 Impact factor: 3.765

6. Effect of phentolamine on isolated guinea-pig atria.

Authors: J Wagner
Journal: Eur J Pharmacol Date: 1970-03 Impact factor: 4.432

7. Effect of ATP on release of intracellular enzymes from damaged cells.

Authors: J H Wilkinson; J M Robinson
Journal: Nature Date: 1974-06-14 Impact factor: 49.962

8. Acetylcholine-induced release of lactate dehydrogenase from isolated perfused rat heart.

Authors: J De Leiris; D Feuvray; C Come
Journal: J Mol Cell Cardiol Date: 1972-08 Impact factor: 5.000

9. [Release of noradrenaline from the isolated perfused heart in acute anoxia and following administration of metabolic poisons].

Authors: L Shahab; A Wollenberger
Journal: Acta Biol Med Ger Date: 1967

10. Serum enzyme determinations in the diagnosis and assessment of myocardial infarction.

Authors: B E Sobel; W E Shell
Journal: Circulation Date: 1972-02 Impact factor: 29.690

6 in total

1. Functional alterations of cardiac subcellular structures during energy deficiency in relation to the metabolic state of the heart muscle cell.

Authors: P G Spieckermann; M M Gebhard; G G Göring; H Kahles; V A Mezger; C J Preusse; M Stellwaag
Journal: Basic Res Cardiol Date: 1980 Jan-Feb Impact factor: 17.165