BACKGROUND: The objective of this study was to determine the pattern of forearm bone loss and its relationship to markers of bone turnover and sex steroids in normal men. This was a longitudinal study over a median interval of 41 months. The study was conducted in Adelaide, Australia. Study participants were 123 healthy male subjects, between the ages of 20 and 83 years. METHODS: Fat-corrected forearm bone mineral content (fcBMC), markers of bone formation (alkaline phosphatase, osteocalcin, procollagen type 1 C-terminal extension peptide) and bone resorption (collagen type I cross-linked telopeptide, hydroxyproline/creatinine, pyridinoline/creatinine, and deoxypyridinoline/creatinine), calculated serum bioavailable testosterone, and serum estradiol were measured. RESULTS: The mean time-weighted rate of change in forearm fcBMC was -0.33% +/- 0.72 (SD) per year. Bone loss commenced after 30 years of age and increased with age (p <.001), particularly after age 70 years. There was no relationship between the rate of change in fcBMC and either markers of bone turnover or serum sex steroids. CONCLUSIONS: In normal men, bone loss increases with age; there does not appear to be any relationship between this loss and either markers of bone turnover or levels of free androgen or estrogen.
BACKGROUND: The objective of this study was to determine the pattern of forearm bone loss and its relationship to markers of bone turnover and sex steroids in normal men. This was a longitudinal study over a median interval of 41 months. The study was conducted in Adelaide, Australia. Study participants were 123 healthy male subjects, between the ages of 20 and 83 years. METHODS: Fat-corrected forearm bone mineral content (fcBMC), markers of bone formation (alkaline phosphatase, osteocalcin, procollagen type 1 C-terminal extension peptide) and bone resorption (collagen type I cross-linked telopeptide, hydroxyproline/creatinine, pyridinoline/creatinine, and deoxypyridinoline/creatinine), calculated serum bioavailable testosterone, and serum estradiol were measured. RESULTS: The mean time-weighted rate of change in forearm fcBMC was -0.33% +/- 0.72 (SD) per year. Bone loss commenced after 30 years of age and increased with age (p <.001), particularly after age 70 years. There was no relationship between the rate of change in fcBMC and either markers of bone turnover or serum sex steroids. CONCLUSIONS: In normal men, bone loss increases with age; there does not appear to be any relationship between this loss and either markers of bone turnover or levels of free androgen or estrogen.
Authors: Manthos G Giannoulis; Finbarr C Martin; K Sreekumaran Nair; A Margot Umpleby; Peter Sonksen Journal: Endocr Rev Date: 2012-03-20 Impact factor: 19.871
Authors: E Gielen; T O'Neill; S Pye; J Adams; K Ward; F Wu; M Laurent; F Claessens; S Boonen; D Vanderschueren; S Verschueren Journal: Osteoporos Int Date: 2014-09-16 Impact factor: 4.507
Authors: Dianne Currier; Jane Pirkis; John Carlin; Louisa Degenhardt; Shyamali C Dharmage; Billie Giles-Corti; Ian Gordon; Lyle Gurrin; Jane Hocking; Anne Kavanagh; Louise A Keogh; Rachel Koelmeyer; Anthony D LaMontagne; Marisa Schlichthorst; George Patton; Lena Sanci; Matthew J Spittal; David M Studdert; Joanne Williams; Dallas R English Journal: BMC Public Health Date: 2016-10-31 Impact factor: 3.295
Authors: Ahmad Nazrun Shuid; Eman El-arabi; Nadia Mohd Effendy; Halimaton Saadiah Abdul Razak; Norliza Muhammad; Norazlina Mohamed; Ima Nirwana Soelaiman Journal: BMC Complement Altern Med Date: 2012-09-12 Impact factor: 3.659