OBJECTIVE: To investigate the implications of the HLA-B locus in the susceptibility to Henoch-Schönlein purpura (HSP) and determine if there are associations with renal and gastrointestinal (GI) manifestations of the disease. METHODS: A retrospective study was performed on an unselected population of patients with HSP from Northwest Spain. Forty-eight Caucasian patients (24 women), 11 of them older than 20 years, were studied. Patients and ethnically matched controls were HLA-B genotyped from DNA using molecular based methods. RESULTS: When patients with HSP were compared with matched controls, no differences in HLA-B frequencies were observed. No HLA-B associations with GI manifestations were observed. In contrast, an increased frequency of HLA-B35 was observed in patients with renal manifestations (10 of 31) compared to those without (0 of 17). No significant distortions in frequency were seen for any other HLA-B alleles with HSP subgroups. CONCLUSION: Our results support a role of HLA-B35 in the susceptibility for nephritis in unselected patients with HSP.
OBJECTIVE: To investigate the implications of the HLA-B locus in the susceptibility to Henoch-Schönlein purpura (HSP) and determine if there are associations with renal and gastrointestinal (GI) manifestations of the disease. METHODS: A retrospective study was performed on an unselected population of patients with HSP from Northwest Spain. Forty-eight Caucasian patients (24 women), 11 of them older than 20 years, were studied. Patients and ethnically matched controls were HLA-B genotyped from DNA using molecular based methods. RESULTS: When patients with HSP were compared with matched controls, no differences in HLA-B frequencies were observed. No HLA-B associations with GI manifestations were observed. In contrast, an increased frequency of HLA-B35 was observed in patients with renal manifestations (10 of 31) compared to those without (0 of 17). No significant distortions in frequency were seen for any other HLA-B alleles with HSP subgroups. CONCLUSION: Our results support a role of HLA-B35 in the susceptibility for nephritis in unselected patients with HSP.
Authors: Mikael Koskela; Julia Nihtilä; Elisa Ylinen; Kaija-Leena Kolho; Matti Nuutinen; Jarmo Ritari; Timo Jahnukainen Journal: Pediatr Nephrol Date: 2021-02-16 Impact factor: 3.714
Authors: Raquel López-Mejías; Fernanda Genre; Belén Sevilla Pérez; Santos Castañeda; Norberto Ortego-Centeno; Javier Llorca; Begoña Ubilla; Sara Remuzgo-Martínez; Verónica Mijares; Trinitario Pina; Vanesa Calvo-Río; Ana Márquez; José A Miranda-Filloy; Antonio Navas Parejo; Marta Conde-Jaldón; Lourdes Ortiz-Fernández; Diego Argila; Maximiliano Aragües; Esteban Rubio; Manuel León Luque; Juan María Blanco-Madrigal; Eva Galíndez-Aguirregoikoa; Francisca González Escribano; J Gonzalo Ocejo-Vinyals; Javier Martín; Ricardo Blanco; Miguel A González-Gay Journal: Arthritis Res Ther Date: 2015-04-14 Impact factor: 5.156