PURPOSE: To determine the utility of CT imaging in identifying patients with dysthyroid optic neuropathy. METHODS: Orbital CT scans of 12 randomly selected patients with dysthyroid optic neuropathy and 15 control subjects with Graves orbitopathy were retrospectively reviewed by two investigators blinded to the clinical data. The clinical diagnosis of optic neuropathy was made by one author before obtaining CT images and was based on clinical features. RESULTS:Optic nerve crowding (P<0.001) and intracranial fat prolapse (P<0.05) were the imaging features independently related to optic neuropathy. A muscle index greater than 50% had excellent sensitivity (100%) but did not have high specificity (47%) for dysthyroid optic neuropathy. Superior ophthalmic vein dilation and proptosis did not show significant relations with optic neuropathy. CONCLUSIONS: This study suggests that patients with Graves orbitopathy who have severe optic nerve crowding, intracranial fat prolapse, and/or muscle index greater than 50% present on orbital CT scans are more likely to have coexisting optic neuropathy.
RCT Entities:
PURPOSE: To determine the utility of CT imaging in identifying patients with dysthyroid optic neuropathy. METHODS: Orbital CT scans of 12 randomly selected patients with dysthyroid optic neuropathy and 15 control subjects with Graves orbitopathy were retrospectively reviewed by two investigators blinded to the clinical data. The clinical diagnosis of optic neuropathy was made by one author before obtaining CT images and was based on clinical features. RESULTS: Optic nerve crowding (P<0.001) and intracranial fat prolapse (P<0.05) were the imaging features independently related to optic neuropathy. A muscle index greater than 50% had excellent sensitivity (100%) but did not have high specificity (47%) for dysthyroid optic neuropathy. Superior ophthalmic vein dilation and proptosis did not show significant relations with optic neuropathy. CONCLUSIONS: This study suggests that patients with Graves orbitopathy who have severe optic nerve crowding, intracranial fat prolapse, and/or muscle index greater than 50% present on orbital CT scans are more likely to have coexisting optic neuropathy.
Authors: Shikha Chaganti; Kevin Mundy; Michael P DeLisi; Katrina M Nelson; Robert L Harrigan; Robert L Galloway; Bennett A Landman; Louise A Mawn Journal: J Digit Imaging Date: 2019-12 Impact factor: 4.056
Authors: David McKeag; Carol Lane; John H Lazarus; Lelio Baldeschi; Kostas Boboridis; A Jane Dickinson; A Iain Hullo; George Kahaly; Gerry Krassas; Claudio Marcocci; Michele Marinò; Maarten P Mourits; Marco Nardi; Christopher Neoh; Jacques Orgiazzi; Petros Perros; Aldo Pinchera; Susanne Pitz; Mark F Prummel; Maria S Sartini; Wilmar M Wiersinga Journal: Br J Ophthalmol Date: 2006-10-11 Impact factor: 4.638
Authors: Shikha Chaganti; Katrina Nelson; Kevin Mundy; Yifu Luo; Robert L Harrigan; Steve Damon; Daniel Fabbri; Louise Mawn; Bennett Landman Journal: Proc SPIE Int Soc Opt Eng Date: 2016-03-21