Haydeh Payami1, Sepideh Zareparsi, Dora James, John Nutt. 1. Department of Neurology, CR131, Oregon Health Sciences University, 3181 SW Sam Jackson Park Rd, Portland, OR 97201, USA. payamih@ohsu.edu
Abstract
CONTEXT: It is unclear whether late-onset Parkinson disease (PD), which is the most typical and most common form of the disease, has a familial component. Evidence for familial aggregation is key to whether research should focus on gene discovery or search for environmental factors. OBJECTIVE: To investigate familial aggregation of early-onset and late-onset PD separately. METHODS: Using survival methods, age-specific risk of PD was calculated and compared for 525 parents and siblings of 117 patients with early-onset PD, 1642 parents and siblings of 343 patients with late-onset PD, and 522 parents and siblings of 114 controls. The index patients were ascertained from a movement disorder clinic. Spouses and friends served as controls. RESULTS: Compared with the relatives of controls, age-specific risk of PD was increased 7.76-fold in the relatives of patients with early-onset disease (P<.001) and 2.95-fold in the relatives of those with late-onset disease (P =.02). CONCLUSIONS: Late-onset PD has a significant familial component. The magnitude of recurrence risk to relatives suggests a genetic etiology, without ruling out the possibility of a coexisting environmental component.
CONTEXT: It is unclear whether late-onset Parkinson disease (PD), which is the most typical and most common form of the disease, has a familial component. Evidence for familial aggregation is key to whether research should focus on gene discovery or search for environmental factors. OBJECTIVE: To investigate familial aggregation of early-onset and late-onset PD separately. METHODS: Using survival methods, age-specific risk of PD was calculated and compared for 525 parents and siblings of 117 patients with early-onset PD, 1642 parents and siblings of 343 patients with late-onset PD, and 522 parents and siblings of 114 controls. The index patients were ascertained from a movement disorder clinic. Spouses and friends served as controls. RESULTS: Compared with the relatives of controls, age-specific risk of PD was increased 7.76-fold in the relatives of patients with early-onset disease (P<.001) and 2.95-fold in the relatives of those with late-onset disease (P =.02). CONCLUSIONS: Late-onset PD has a significant familial component. The magnitude of recurrence risk to relatives suggests a genetic etiology, without ruling out the possibility of a coexisting environmental component.
Authors: Gregory M Pontone; Justin Palanci; O Joseph Bienvenu; Kung-Yee Liang; Gerald Nestadt; Peter V Rabins; James R Williams; Laura Marsh Journal: J Neuropsychiatry Clin Neurosci Date: 2011 Impact factor: 2.198
Authors: Michael Y Shino; Valerie McGuire; Stephen K Van Den Eeden; Caroline M Tanner; Rita Popat; Amethyst Leimpeter; Allan L Bernstein; Lorene M Nelson Journal: Mov Disord Date: 2010-11-15 Impact factor: 10.338
Authors: Sarah Teixeira Camargos; Leonardo Oliveira Dornas; Parastoo Momeni; Andrew Lees; John Hardy; Andrew Singleton; Francisco Cardoso Journal: Mov Disord Date: 2009-04-15 Impact factor: 10.338
Authors: Ami R Rosen; N Kyle Steenland; John Hanfelt; Stewart A Factor; James J Lah; Allan I Levey Journal: Neurogenetics Date: 2007-09-06 Impact factor: 2.660
Authors: Margaux F Keller; Mohamad Saad; Jose Bras; Francesco Bettella; Nayia Nicolaou; Javier Simón-Sánchez; Florian Mittag; Finja Büchel; Manu Sharma; J Raphael Gibbs; Claudia Schulte; Valentina Moskvina; Alexandra Durr; Peter Holmans; Laura L Kilarski; Rita Guerreiro; Dena G Hernandez; Alexis Brice; Pauli Ylikotila; Hreinn Stefánsson; Kari Majamaa; Huw R Morris; Nigel Williams; Thomas Gasser; Peter Heutink; Nicholas W Wood; John Hardy; Maria Martinez; Andrew B Singleton; Michael A Nalls Journal: Hum Mol Genet Date: 2012-08-13 Impact factor: 6.150