Susan R Kahn1, Andrew Hirsch, Ian Shrier. 1. Center for Clinical Epidemiology and Community Studies, Sir Mortimer B. Davis Jewish General Hospital, 3755 Cote Ste, Catherine Room A-114, Montreal, Quebec, Canada H3T 1E2. susan.kahn@mcgill.ca
Abstract
BACKGROUND: Postthrombotic syndrome (PTS) is a frequent chronic complication of deep venous thrombosis, yet its impact on health-related quality of life has not been well characterized. We compared generic and venous disease-specific quality of life in patients with and without PTS, and assessed whether quality of life correlated with severity of PTS. METHODS: Subjects with previous deep venous thrombosis were participants in a study of the effects of exercise after deep venous thrombosis. We ascertained PTS and its severity using a validated clinical scale. Subjects completed generic (the 36-Item Short-Form Health Survey) and disease-specific (Venous Insufficiency Epidemiologic and Economic Study quality-of-life questionnaire [VEINES-QOL] and its validated subscale of 10 items on venous symptoms [VEINES-Sym]) quality-of-life measures. Age- and sex-adjusted mean quality-of-life scores were compared in patients with and without PTS, and by severity of PTS. RESULTS: Of the 41 subjects (mean age, 51.2 years), 19 (46%) had PTS. Subjects with PTS had significantly worse disease-specific quality-of-life scores than those without PTS (mean +/- SD VEINES-QOL score, 44.5 +/- 11.6 vs 54.8 +/- 5.4, respectively [P<.001]; mean +/- SD VEINES-Sym score, 45.6 +/- 11.4 vs 54.1 +/- 6.7, respectively [P =.003]), which worsened significantly with increasing severity of PTS. We found no differences in generic quality-of-life scores between subject groups. CONCLUSIONS: Postthrombotic syndrome has a significant impact on disease-specific quality of life that may not be captured by generic quality-of-life measures. Patient-based quality-of-life measures correlated well with physician-assessed PTS. Further research is indicated to assess the value of including quality of life as a routine measure of outcome in clinical studies of patients with deep venous thrombosis and PTS.
BACKGROUND:Postthrombotic syndrome (PTS) is a frequent chronic complication of deep venous thrombosis, yet its impact on health-related quality of life has not been well characterized. We compared generic and venous disease-specific quality of life in patients with and without PTS, and assessed whether quality of life correlated with severity of PTS. METHODS: Subjects with previous deep venous thrombosis were participants in a study of the effects of exercise after deep venous thrombosis. We ascertained PTS and its severity using a validated clinical scale. Subjects completed generic (the 36-Item Short-Form Health Survey) and disease-specific (Venous Insufficiency Epidemiologic and Economic Study quality-of-life questionnaire [VEINES-QOL] and its validated subscale of 10 items on venous symptoms [VEINES-Sym]) quality-of-life measures. Age- and sex-adjusted mean quality-of-life scores were compared in patients with and without PTS, and by severity of PTS. RESULTS: Of the 41 subjects (mean age, 51.2 years), 19 (46%) had PTS. Subjects with PTS had significantly worse disease-specific quality-of-life scores than those without PTS (mean +/- SD VEINES-QOL score, 44.5 +/- 11.6 vs 54.8 +/- 5.4, respectively [P<.001]; mean +/- SD VEINES-Sym score, 45.6 +/- 11.4 vs 54.1 +/- 6.7, respectively [P =.003]), which worsened significantly with increasing severity of PTS. We found no differences in generic quality-of-life scores between subject groups. CONCLUSIONS:Postthrombotic syndrome has a significant impact on disease-specific quality of life that may not be captured by generic quality-of-life measures. Patient-based quality-of-life measures correlated well with physician-assessed PTS. Further research is indicated to assess the value of including quality of life as a routine measure of outcome in clinical studies of patients with deep venous thrombosis and PTS.
Authors: Aneel A Ashrani; Marc D Silverstein; Thom W Rooke; Brian D Lahr; Tanya M Petterson; Kent R Bailey; L Joseph Melton; John A Heit Journal: Vasc Med Date: 2010-10 Impact factor: 3.239
Authors: Paolo Prandoni; Enrico Bernardi; Antonio Marchiori; Anthonie W A Lensing; Martin H Prins; Sabina Villalta; Paola Bagatella; Donatella Sartor; Andrea Piccioli; Paolo Simioni; Antonio Pagnan; Antonio Girolami Journal: BMJ Date: 2004-07-15
Authors: David Liu; Erica Peterson; James Dooner; Mark Baerlocher; Leslie Zypchen; Joel Gagnon; Michael Delorme; Chad Kim Sing; Jason Wong; Randolph Guzman; Gavin Greenfield; Otto Moodley; Paul Yenson Journal: CMAJ Date: 2015-09-28 Impact factor: 8.262
Authors: Susan R Kahn; Ian Shrier; Stan Shapiro; Adrielle H Houweling; Andrew M Hirsch; Robert D Reid; Clive Kearon; Khalil Rabhi; Marc A Rodger; Michael J Kovacs; David R Anderson; Philip S Wells Journal: CMAJ Date: 2010-11-22 Impact factor: 8.262