Literature DB >> 12019132

Cloning of a cation efflux pump gene associated with chlorhexidine resistance in Klebsiella pneumoniae.

Chi-Tai Fang1, Haur-Chuan Chen, Yi-Ping Chuang, Shan-Chwen Chang, Jin-Town Wang.   

Abstract

Expression libraries of a chlorhexidine-resistant Klebsiella pneumoniae strain were constructed and transformed into Escherichia coli XLOLR. Twenty chlorhexidine-resistant transformants were obtained after selection. All clones contained a novel 903-nucleotide locus. Its sequences were compatible with a cation efflux pump, and the locus was thus designated as cepA. Retransformation using cepA-containing plasmids conferred chlorhexidine resistance to both XLOLR and a chlorhexidine-sensitive K. pneumoniae strain. Therefore, CepA is associated with chlorhexidine resistance and may act as a cation efflux pump.

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Year:  2002        PMID： 12019132      PMCID： PMC127239          DOI： 10.1128/AAC.46.6.2024-2028.2002

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


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