Literature DB >> 12019128

Effects of synthetic siderophores on proliferation of Plasmodium falciparum in infected human erythrocytes.

Andrea Rotheneder1, Gernot Fritsche, Lothar Heinisch, Ute Möllmann, Susanne Heggemann, Clara Larcher, Günter Weiss.   

Abstract

Because iron is essential for Plasmodium falciparum, we investigated the in vitro potential of various synthetic siderophores to kill P. falciparum in infected human erythrocytes. The substances with the most promising profile, i.e., low 50% lethal doses for plasmodia and minimum toxicity towards mammalian cells, were siderophores with an acylated monocatecholate or a triscatecholate as substituent.

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Year:  2002        PMID： 12019128      PMCID： PMC127273          DOI： 10.1128/AAC.46.6.2010-2013.2002

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

1.  8-Acyloxy-1,3-benzoxazine-2,4-diones as siderophore components for antibiotics.

Authors:  S Wittmann; I Scherlitz-Hofmann; U Möllmann; D Ankel-Fuchs; L Heinisch
Journal:  Arzneimittelforschung       Date:  2000-08

2.  Regulatory interactions between iron and nitric oxide metabolism for immune defense against Plasmodium falciparum infection.

Authors:  G Fritsche; C Larcher; H Schennach; G Weiss
Journal:  J Infect Dis       Date:  2001-03-23       Impact factor: 5.226

3.  Stage-dependent effect of deferoxamine on growth of Plasmodium falciparum in vitro.

Authors:  S Whitehead; T E Peto
Journal:  Blood       Date:  1990-09-15       Impact factor: 22.113

4.  New artificial siderophores based on a monosaccharide scaffold.

Authors:  S Heggemann; M Schnabelrauch; D Klemm; U Möllmann; R Reissbrodt; L Heinisch
Journal:  Biometals       Date:  2001-03       Impact factor: 2.949

5.  Antimalarial effect of HBED and other phenolic and catecholic iron chelators.

Authors:  A M Yinnon; E N Theanacho; R W Grady; D T Spira; C Hershko
Journal:  Blood       Date:  1989-11-01       Impact factor: 22.113

6.  A reappraisal of the effects of iron and desferrioxamine on the growth of Plasmodium falciparum 'in vitro': the unimportance of serum iron.

Authors:  T E Peto; J L Thompson
Journal:  Br J Haematol       Date:  1986-06       Impact factor: 6.998

7.  Desferrioxamine suppresses Plasmodium falciparum in Aotus monkeys.

Authors:  S Pollack; R N Rossan; D E Davidson; A Escajadillo
Journal:  Proc Soc Exp Biol Med       Date:  1987-02

8.  The adverse effect of iron repletion on the course of certain infections.

Authors:  M J Murray; A B Murray; M B Murray; C J Murray
Journal:  Br Med J       Date:  1978-10-21

9.  Effect of iron chelation therapy on mortality in Zambian children with cerebral malaria.

Authors:  P E Thuma; G F Mabeza; G Biemba; G J Bhat; C E McLaren; V M Moyo; S Zulu; H Khumalo; P Mabeza; A M'Hango; D Parry; A A Poltera; G M Brittenham; V R Gordeuk
Journal:  Trans R Soc Trop Med Hyg       Date:  1998 Mar-Apr       Impact factor: 2.184

10.  The effect of iron therapy on malarial infection in Papua New Guinean schoolchildren.

Authors:  P W Harvey; P F Heywood; M C Nesheim; K Galme; M Zegans; J P Habicht; L S Stephenson; K L Radimer; B Brabin; K Forsyth
Journal:  Am J Trop Med Hyg       Date:  1989-01       Impact factor: 2.345
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  3 in total

1.  Production of metabolites as bacterial responses to the marine environment.

Authors:  Carla C C R de Carvalho; Pedro Fernandes
Journal:  Mar Drugs       Date:  2010-03-17       Impact factor: 5.118

Review 2.  Superinfection in malaria: Plasmodium shows its iron will.

Authors:  Sílvia Portugal; Hal Drakesmith; Maria M Mota
Journal:  EMBO Rep       Date:  2011-12-01       Impact factor: 8.807

3.  Signalling and Bioactive Metabolites from Streptomyces sp. RK44.

Authors:  Qing Fang; Fleurdeliz Maglangit; Linrui Wu; Rainer Ebel; Kwaku Kyeremeh; Jeanette H Andersen; Frederick Annang; Guiomar Pérez-Moreno; Fernando Reyes; Hai Deng
Journal:  Molecules       Date:  2020-01-22       Impact factor: 4.411
  3 in total

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