Literature DB >> 12019124

Impact of N-chlorotaurine on viability and production of secreted aspartyl proteinases of Candida spp.

Markus Nagl1, Andreas Gruber, Anita Fuchs, Claudia P Lell, Eva-Maria Lemberger, Margarete Borg-Von Zepelin, Reinhard Würzner.   

Abstract

N-Chlorotaurine, an endogenous long-lived oxidant, demonstrated fungicidal activity against Candida spp. and a postantifungal effect. Secreted aspartyl proteinases, important fungal virulence factors, proved to be a first target of impact. These results provide support for the topical application of N-chlorotaurine as an antimicrobial agent in yeast infections.

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Year:  2002        PMID： 12019124      PMCID： PMC127226          DOI： 10.1128/AAC.46.6.1996-1999.2002

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

Review 1.  Candida albicans proteinases: resolving the mystery of a gene family.

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Review 2.  Putative virulence factors of Candida albicans.

Authors:  J E Cutler
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3.  Activity of N-chlorotaurine against herpes simplex- and adenoviruses.

Authors:  M Nagl; C Larcher; W Gottardi
Journal:  Antiviral Res       Date:  1998-04       Impact factor: 5.970

4.  Evaluation of bactericidal activity and lag of regrowth (postantibiotic effect) of five antiseptics on nine bacterial pathogens.

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5.  In vitro and in vivo anticandidal activity of human immunodeficiency virus protease inhibitors.

Authors:  A Cassone; F De Bernardis; A Torosantucci; E Tacconelli; M Tumbarello; R Cauda
Journal:  J Infect Dis       Date:  1999-08       Impact factor: 5.226

6.  The postantibiotic effect of N-chlorotaurine on Staphylococcus aureus. Application in the mouse peritonitis model.

Authors:  M Nagl; P Hengster; E Semenitz; W Gottardi
Journal:  J Antimicrob Chemother       Date:  1999-06       Impact factor: 5.790

7.  Human immunodeficiency virus type 1 gp160 and gp41 binding to Candida albicans selectively enhances candidal virulence in vitro.

Authors:  A Gruber; E Lukasser-Vogl; M Borg-von Zepelin; M P Dierich; R Würzner
Journal:  J Infect Dis       Date:  1998-04       Impact factor: 5.226

8.  Evidence that members of the secretory aspartyl proteinase gene family, in particular SAP2, are virulence factors for Candida vaginitis.

Authors:  F De Bernardis; S Arancia; L Morelli; B Hube; D Sanglard; W Schäfer; A Cassone
Journal:  J Infect Dis       Date:  1999-01       Impact factor: 5.226

9.  Increased expression of Candida albicans secretory proteinase, a putative virulence factor, in isolates from human immunodeficiency virus-positive patients.

Authors:  M W Ollert; C Wende; M Görlich; C G McMullan-Vogel; M Borg-von Zepelin; C W Vogel; H C Korting
Journal:  J Clin Microbiol       Date:  1995-10       Impact factor: 5.948

10.  Generation of nitrogen-chlorine oxidants by human phagocytes.

Authors:  S T Test; M B Lampert; P J Ossanna; J G Thoene; S J Weiss
Journal:  J Clin Invest       Date:  1984-10       Impact factor: 14.808
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  14 in total

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2.  Chemical characterization and biological properties of NVC-422, a novel, stable N-chlorotaurine analog.

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3.  Bactericidal and Fungicidal Activity of N-Chlorotaurine Is Enhanced in Cystic Fibrosis Sputum Medium.

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Review 4.  Current Opinion on the Therapeutic Capacity of Taurine-Containing Halogen Derivatives in Infectious and Inflammatory Diseases.

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5.  Tolerability of N-chlorotaurine plus ammonium chloride in the rabbit and human eye--a phase 1 clinical study.

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6.  NVC-422 inactivates Staphylococcus aureus toxins.

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7.  Basidiomycete metabolites attenuate virulence properties of Candida albicans in vitro.

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Journal:  Mycoses       Date:  2008-04-16       Impact factor: 4.377

8.  N-Chlorotaurine Exhibits Fungicidal Activity against Therapy-Refractory Scedosporium Species and Lomentospora prolificans.

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9.  Tolerability of inhaled N-chlorotaurine in an acute pig streptococcal lower airway inflammation model.

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10.  N-chlorotaurine, a long-lived oxidant produced by human leukocytes, inactivates Shiga toxin of enterohemorrhagic Escherichia coli.

Authors:  Christian Eitzinger; Silvia Ehrlenbach; Herbert Lindner; Leopold Kremser; Waldemar Gottardi; Dmitri Debabov; Mark Anderson; Markus Nagl; Dorothea Orth
Journal:  PLoS One       Date:  2012-11-06       Impact factor: 3.240
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