OBJECTIVE: To examine previous use of nicotine replacement therapy (NRT) on the smoking-cessation efficacy of bupropion sustained release (SR). METHODS: Secondary analysis of a parallel-group, randomized, double-blind, placebo-controlled study. Smokers who had, based on self-report, no previous history of NRT (N = 453) or who had used NRT at least once (N = 440) were randomized to receive placebo, bupropion SR, nicotine transdermal system (NTS), or a combination of bupropion SR and NTS. RESULTS:Bupropion SR showed similar efficacy in participants with or without previous use of NRT. CONCLUSION:Bupropion SR is effective in promoting smoking abstinence regardless of prior NRT use.
RCT Entities:
OBJECTIVE: To examine previous use of nicotine replacement therapy (NRT) on the smoking-cessation efficacy of bupropion sustained release (SR). METHODS: Secondary analysis of a parallel-group, randomized, double-blind, placebo-controlled study. Smokers who had, based on self-report, no previous history of NRT (N = 453) or who had used NRT at least once (N = 440) were randomized to receive placebo, bupropion SR, nicotine transdermal system (NTS), or a combination of bupropion SR and NTS. RESULTS:Bupropion SR showed similar efficacy in participants with or without previous use of NRT. CONCLUSION:Bupropion SR is effective in promoting smoking abstinence regardless of prior NRT use.
Authors: Bryan W Heckman; K Michael Cummings; Karin A Kasza; Ron Borland; Jessica L Burris; Geoffrey T Fong; Ann McNeill; Matthew J Carpenter Journal: Am J Prev Med Date: 2017-03-20 Impact factor: 5.043
Authors: Lisa Sanderson Cox; Ana-Paula Cupertino; Laura M Mussulman; Niaman Nazir; K Allen Greiner; Jonathan D Mahnken; Jasjit S Ahluwalia; Edward F Ellerbeck Journal: Prev Med Date: 2008-05-03 Impact factor: 4.018
Authors: D Gonzales; P Hajek; L Pliamm; K Nackaerts; L-J Tseng; T D McRae; J Treadow Journal: Clin Pharmacol Ther Date: 2014-06-09 Impact factor: 6.875