Literature DB >> 1201861

Fragmentation of human IgG by a new protease isolated from the basidiomycete Armillaria mellea.

I M Hunneyball, D R Stanworth.   

Abstract

Digestion of human IgG by a new lysine-specific protease, isolated from the basidiomycete Armillaria mellea, produced Fc and Fab fragments similar to those produced by papain digestion of the same molecule. Digestion appeared to be restricted to a single cleavage point within the hinge region of the IgG molecule. Myeloma proteins of IgG1, IgG3 and IgG4 subclasses were found to be digested at an extremely rapid rate whereas IgG2 myeloma proteins appeared to be resistant to digestion by this enzyme.

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Year:  1975        PMID： 1201861      PMCID： PMC1446008     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  8 in total

1.  The use of baboon IgG-sensitized sheep erythrocytes as an alternative indicator system in the study of the interaction of rheumatoid factor with human IgG.

Authors:  G A Stewart; I M Hunneyball; D R Stanworth
Journal:  Immunochemistry       Date:  1975-08

2.  Structural units of human 7S gamma globulin.

Authors:  E C FRANKLIN
Journal:  J Clin Invest       Date:  1960-12       Impact factor: 14.808

3.  Reaction of rheumatoid sera with fragments of papain-digested rabbit gamma globulin.

Authors:  J W GOODMAN
Journal:  Proc Soc Exp Biol Med       Date:  1961-04

4.  Biologically active water-insoluble protein polymers. I. Their use for isolation of antigens and antibodies.

Authors:  S Avrameas; T Ternynck
Journal:  J Biol Chem       Date:  1967-04-10       Impact factor: 5.157

5.  Biological activities associated with the Facb fragment of rabbit IgG.

Authors:  G A Stewart; A K Smith; D R Stanworth
Journal:  Immunochemistry       Date:  1973-11

6.  Subfragments from the Fc fragment of human immunoglobulin G. Isolation and physicochemical charaterization.

Authors:  M W Turner; H Bennich
Journal:  Biochem J       Date:  1968-03       Impact factor: 3.857

7.  The covalent structure of an entire gammaG immunoglobulin molecule.

Authors:  G M Edelman; B A Cunningham; W E Gall; P D Gottlieb; U Rutishauser; M J Waxdal
Journal:  Proc Natl Acad Sci U S A       Date:  1969-05       Impact factor: 11.205

8.  Reactivity of rheumatoid factor with rabbit gamma-globulin.

Authors:  F C McDuffie; T Oikawa; I Nishi
Journal:  J Immunol       Date:  1965-10       Impact factor: 5.422
  8 in total
  1 in total

1.  Subfragmentation of the Fc fragment of human IgG1 myeloma protein by thermolysin.

Authors:  I M Hunneyball; D R Stanworth
Journal:  Immunology       Date:  1976-04       Impact factor: 7.397
  1 in total

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