Literature DB >> 1201755

Calcitonin biosynthesis: evidence for a precursor.

F Moya, A Nieto, J L R-Candela.   

Abstract

Calcitonin biosynthesis has been studied in chicken ultimobranchial glands incubated in vitro in the presence of radioactive amino acids. The results obtained suggest the existence of a biosynthetic precursor of higher molecular weight or procalcitonin. This precursor has been identified by pulse-chase experiments, molecular weight determinations, biological activity measurements and analysis of tryptic peptides. Its molecular weight is about 13000 (calcitonin, about 3500) as determined by polyacrylamide gel electrophoresis. Procalcitonin is present in small amounts in chicken ultimobranchial glands and it is biologically active in rats.

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Year:  1975        PMID： 1201755     DOI： 10.1111/j.1432-1033.1975.tb02176.x

Source DB:  PubMed          Journal:  Eur J Biochem        ISSN： 0014-2956


  18 in total

Review 1.  Procalcitonin in acute cardiac patients.

Authors:  Claudio Picariello; Chiara Lazzeri; Serafina Valente; Marco Chiostri; Gian Franco Gensini
Journal:  Intern Emerg Med       Date:  2010-09-29       Impact factor: 3.397

Review 2.  Procalcitonin: present and future.

Authors:  H H Liu; J B Guo; Y Geng; L Su
Journal:  Ir J Med Sci       Date:  2015-07-10       Impact factor: 1.568

Review 3.  Overview of procalcitonin in pregnancy and in pre-eclampsia.

Authors:  A Mangogna; C Agostinis; G Ricci; F Romano; R Bulla
Journal:  Clin Exp Immunol       Date:  2019-06-13       Impact factor: 4.330

4.  Single cellular origin of somatostatin and calcitonin in the rat thyroid gland.

Authors:  S Van Noorden; J M Polak; A G Pearse
Journal:  Histochemistry       Date:  1977-08-22

Review 5.  Predictors of treatment failure and clinical stability in patients with community acquired pneumonia.

Authors:  Deirdre Morley; Antoni Torres; Catia Cillóniz; Ignacio Martin-Loeches
Journal:  Ann Transl Med       Date:  2017-11

6.  Purification and partial characterization of high-molecular-weight forms of ectopic calcitonin from a human bronchial carcinoma cell line.

Authors:  J Lumsden; J Ham; M L Ellison
Journal:  Biochem J       Date:  1980-10-01       Impact factor: 3.857

7.  Characterization of rat calcitonin mRNA.

Authors:  S G Amara; D N David; M G Rosenfeld; B A Roos; R M Evans
Journal:  Proc Natl Acad Sci U S A       Date:  1980-08       Impact factor: 11.205

Review 8.  CGRP and migraine: could PACAP play a role too?

Authors:  Eric A Kaiser; Andrew F Russo
Journal:  Neuropeptides       Date:  2013-10-23       Impact factor: 3.286

9.  Characterization of the immunochemical forms of calcitonin released by a medullary thyroid carcinoma in tissue culture.

Authors:  D Goltzman; A S Tischler
Journal:  J Clin Invest       Date:  1978-02       Impact factor: 14.808

10.  Novel biomarkers to detect infection in revision hip and knee arthroplasties.

Authors:  Mathias Glehr; Joerg Friesenbichler; Günter Hofmann; Gerwin Alexander Bernhardt; Maximilian Zacherl; Alexander Avian; Reinhard Windhager; Andreas Leithner
Journal:  Clin Orthop Relat Res       Date:  2013-04-23       Impact factor: 4.176
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