[Studies on the synthesis and experimental therapeutic effects of metal chlorin on 60Co-irridiated mice].

Pheophorbide a and pyropheophorbide a were prepared by acid degradation of crude chlorophylls isolated from silkworm excrement. Pheophorbide a was further degraded to chlorin e6 monomethyl ester in alkaline methanol in absence of oxygen. Pure purpurin 18 was directly prepared from alkali degradation of silkworm excrement crude chlorophylls in presence of oxygen. Nine chlorin complexes of Co, Cu and Zn were synthesized for the first time. Preliminary pharmacological tests showed that chlorin e6 monomethyl ester copper complex(7) could increase survival and prolong the surviving time of 60Co-irridiated mice significantly.