Literature DB >> 12016302

RNA silencing: the genome's immune system.

Ronald H A Plasterk1.   

Abstract

Genomes are databases sensitive to invasion by viruses. In recent years, a defense mechanism has been discovered, which turns out to be conserved among eukaryotes. The system can be compared to the immune system in several ways: It has specificity against foreign elements and the ability to amplify and raise a massive response against an invading nucleic acid. The latter property is beginning to be understood at the molecular level.

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Year:  2002        PMID: 12016302     DOI: 10.1126/science.1072148

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  111 in total

1.  Similar behaviour of single-strand and double-strand siRNAs suggests they act through a common RNAi pathway.

Authors:  Torgeir Holen; Mohammed Amarzguioui; Eshrat Babaie; Hans Prydz
Journal:  Nucleic Acids Res       Date:  2003-05-01       Impact factor: 16.971

2.  Independent combinatorial effect of antisense oligonucleotides and RNAi-mediated specific inhibition of the recombinant rat P2X3 receptor.

Authors:  Maja Hemmings-Mieszczak; Gabriele Dorn; François J Natt; Jonathan Hall; William L Wishart
Journal:  Nucleic Acids Res       Date:  2003-04-15       Impact factor: 16.971

3.  Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs).

Authors:  Stephan P Persengiev; Xiaochun Zhu; Michael R Green
Journal:  RNA       Date:  2004-01       Impact factor: 4.942

4.  Tolerance for mutations and chemical modifications in a siRNA.

Authors:  Mohammed Amarzguioui; Torgeir Holen; Eshrat Babaie; Hans Prydz
Journal:  Nucleic Acids Res       Date:  2003-01-15       Impact factor: 16.971

5.  A biochemical framework for RNA silencing in plants.

Authors:  Guiliang Tang; Brenda J Reinhart; David P Bartel; Phillip D Zamore
Journal:  Genes Dev       Date:  2003-01-01       Impact factor: 11.361

6.  The maize genome contains a helitron insertion.

Authors:  Shailesh K Lal; Michael J Giroux; Volker Brendel; C Eduardo Vallejos; L Curtis Hannah
Journal:  Plant Cell       Date:  2003-02       Impact factor: 11.277

Review 7.  Molecular characterization of the genomic region linked with apomixis in Pennisetum/Cenchrus.

Authors:  Peggy Ozias-Akins; Yukio Akiyama; Wayne W Hanna
Journal:  Funct Integr Genomics       Date:  2003-06-19       Impact factor: 3.410

Review 8.  RNA interference: from an ancient mechanism to a state of the art therapeutic application?

Authors:  Christoph Arenz; Ute Schepers
Journal:  Naturwissenschaften       Date:  2003-07-23

Review 9.  Recognizing the enemy within: licensing RNA-guided genome defense.

Authors:  Phillip A Dumesic; Hiten D Madhani
Journal:  Trends Biochem Sci       Date:  2013-11-23       Impact factor: 13.807

10.  Tomato mosaic virus replication protein suppresses virus-targeted posttranscriptional gene silencing.

Authors:  Kenji Kubota; Shinya Tsuda; Atsushi Tamai; Tetsuo Meshi
Journal:  J Virol       Date:  2003-10       Impact factor: 5.103

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