Literature DB >> 12015327

The role of single-stranded DNA and polymerase alpha in establishing the ATR, Hus1 DNA replication checkpoint.

Zhongsheng You1, Lindsay Kong, John Newport.   

Abstract

Using a nucleus-free DNA replication system we have investigated the roles of Xenopus ATR (XATR) and Hus1 (Xhus1) as the DNA replication checkpoint sensors. Like XATR, Xhus1 is required for the checkpoint-dependent phosphorylation of Xchk1 and associates with chromatin in an initiation-dependent manner. While removal of replication protein A inhibits chromatin association of both XATR and Xhus1, removal of polymerase alpha only disrupts chromatin association of Xhus1. In addition, chromatin association of XATR and Xhus1 are independent of each other. Finally, like XATR, Xhus1 associates with chromatin in unperturbed S phase and dissociates from chromatin following completion of DNA replication.

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Year:  2002        PMID： 12015327     DOI： 10.1074/jbc.M204120200

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  42 in total

1.  Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities.

Authors:  Keziban Unsal-Kaçmaz; Aziz Sancar
Journal:  Mol Cell Biol       Date:  2004-02       Impact factor: 4.272

Review 2.  DNA replication: a complex matter.

Authors:  Isabelle Frouin; Alessandra Montecucco; Silvio Spadari; Giovanni Maga
Journal:  EMBO Rep       Date:  2003-07       Impact factor: 8.807

3.  A requirement for replication in activation of the ATR-dependent DNA damage checkpoint.

Authors:  Patrick J Lupardus; Tony Byun; Muh-Ching Yee; Mohammad Hekmat-Nejad; Karlene A Cimprich
Journal:  Genes Dev       Date:  2002-09-15       Impact factor: 11.361

Review 4.  Eukaryotic MCM proteins: beyond replication initiation.

Authors:  Susan L Forsburg
Journal:  Microbiol Mol Biol Rev       Date:  2004-03       Impact factor: 11.056

5.  ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation.

Authors:  Heather L Ball; Jeremy S Myers; David Cortez
Journal:  Mol Biol Cell       Date:  2005-03-02       Impact factor: 4.138

6.  Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.

Authors:  Tony S Byun; Marcin Pacek; Muh-ching Yee; Johannes C Walter; Karlene A Cimprich
Journal:  Genes Dev       Date:  2005-04-15       Impact factor: 11.361

7.  Roles of replication fork-interacting and Chk1-activating domains from Claspin in a DNA replication checkpoint response.

Authors:  Joon Lee; Daniel A Gold; Anna Shevchenko; Andrej Shevchenko; William G Dunphy
Journal:  Mol Biol Cell       Date:  2005-09-07       Impact factor: 4.138

8.  Recruitment of DNA damage checkpoint proteins to damage in transcribed and nontranscribed sequences.

Authors:  Guochun Jiang; Aziz Sancar
Journal:  Mol Cell Biol       Date:  2006-01       Impact factor: 4.272

9.  Mcl1p is a polymerase alpha replication accessory factor important for S-phase DNA damage survival.

Authors:  Dewight R Williams; J R McIntosh
Journal:  Eukaryot Cell       Date:  2005-01

10.  The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.

Authors:  Sinny Delacroix; Jill M Wagner; Masahiko Kobayashi; Ken-ichi Yamamoto; Larry M Karnitz
Journal:  Genes Dev       Date:  2007-06-15       Impact factor: 11.361
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