Literature DB >> 1201470

The myocardial effects of pancuronium.

P C Duke, H Fung, J Gartner.   

Abstract

The effect of pancuronium on myocardial contractility was studied in three different animal preparations. Pancuronium produced no change in isometric contraction of rabbit atrial or cat papillary muscle but displaced the acetylcholine dose-response curve to the right in the papillary muscle preparations, verifying a muscarinic blocking effect of this drug. In atropinized dogs in vivo pancuronium produced no significant change in the cardiovascular parameters studied. These studies show that pancuronium exerts its cardiovascular effects primarily by blocking muscarinic receptors in the heart.

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Year:  1975        PMID： 1201470     DOI： 10.1007/bf03013316

Source DB:  PubMed          Journal:  Can Anaesth Soc J        ISSN： 0008-2856


  8 in total

1.  Cardiovascular effects of pancuronium in man.

Authors:  G R Kelman; B R Kennedy
Journal:  Br J Anaesth       Date:  1971-04       Impact factor: 9.166

2.  The hemodynamic effects of pancuronium and d-tubocurarine in anesthetized patients.

Authors:  R K Stoelting
Journal:  Anesthesiology       Date:  1972-06       Impact factor: 7.892

3.  The immediate cardiovascular effects of pancuronium, alcuronium and tubocurarine in man.

Authors:  A J Coleman; J W Downing; W P Leary; D G Moyes; M Styles
Journal:  Anaesthesia       Date:  1972-10       Impact factor: 6.955

4.  Specific blockade of cardiac muscarinic receptors by pancuronium bromide.

Authors:  P R Saxena; I L Bonta
Journal:  Arch Int Pharmacodyn Ther       Date:  1971-02

5.  Mechanism of selective cardiac vagolytic action of pancuronium bromide. Specific blockade of cardiac muscarinic receptors.

Authors:  P R Saxena; I L Bonta
Journal:  Eur J Pharmacol       Date:  1970       Impact factor: 4.432

6.  The cardiovascular effects of pancuronium bromide.

Authors:  L Loh
Journal:  Anaesthesia       Date:  1970-07       Impact factor: 6.955

7.  The effect of pancuronium bromide on plasma norepinepharine and cortisol concentrations during thiamylal induction.

Authors:  E K Zsigmond; A Matsuki; S P Kothary; R C Kelsch
Journal:  Can Anaesth Soc J       Date:  1974-03

8.  Pharmacological interaction between pancuronium bromide and anaesthetics.

Authors:  I L Bonta; E M Goorissen; F H Derkx
Journal:  Eur J Pharmacol       Date:  1968-08       Impact factor: 4.432
  8 in total
  4 in total

1.  Arrhythmias under general anesthesia in a patient with undiagnosed mitral valve prolapse: case report.

Authors:  P Boatwright; E Malsch
Journal:  Anesth Prog       Date:  1982 Sep-Oct

2.  Lack of effects of d-tubocurarine and pancuronium on the slow action potential of the guinea pig papillary muscle.

Authors:  H Arimura; Y Ikemoto; T Ito; J Yoshitake
Journal:  Can Anaesth Soc J       Date:  1985-09

3.  Cardiovascular effects of pancuronium in patients anaesthetized with enflurane and fluroxene.

Authors:  A L Pauca; P Skovsted
Journal:  Can Anaesth Soc J       Date:  1981-01

4.  Positive inotropic and chronotropic effects of pancuronium and vecuronium in the canine blood-pefused papillary muscle and sinoatrial node preparations.

Authors:  M Manabe; S Motomura; T Kumazawa; I Ookawa; T Oguchi
Journal:  J Anesth       Date:  1988-09-01       Impact factor: 2.078
  4 in total

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