Literature DB >> 12012726

Circling mouse, a spontaneous mutant in the inner ear.

Jeong Woong Lee1, Zae Young Ryoo, Eun Ju Lee, Sung Hwa Hong, Won Ho Chung, Hoon Taek Lee, Kil Saeng Chung, Tae Yoon Kim, Yang Seok Oh, Jun Gyo Suh.   

Abstract

A spontaneous mutant was established in the ICR mouse strain. The affected mice became hyperactive at about 7 days of age, and then showed circling behavior. The body weight decreased significantly 2 weeks after birth, and developmental defects were revealed in the middle ear, cochlea, cochlear nerve, and semicircular canal areas. The mutation was inherited by an autosomal single recessive gene and is referred to as cir.

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Year:  2002        PMID: 12012726     DOI: 10.1538/expanim.51.167

Source DB:  PubMed          Journal:  Exp Anim        ISSN: 0007-5124


  8 in total

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5.  Decreased Immunoreactivities and Functions of the Chloride Transporters, KCC2 and NKCC1, in the Lateral Superior Olive Neurons of Circling Mice.

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6.  Subcellular localization of the transmembrane inner ear (Tmie) protein in a stable Tmie-expressing cell line.

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7.  Expression of deafness protein Tmie in postnatal developmental stages of C57BL/6J mice.

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8.  Over-expression of myosin7A in cochlear hair cells of circling mice.

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  8 in total

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