Regeneration of intact spleen in a heterotropic site in splenectomized mice.

The regeneration of intact spleens implanted in the sacrospinal areas of splenectomized mice was studied by light microscopy. The weight of the implanted tissue was not fully regenerated 50 days after implantation. The pattern of embryonic development of the spleen was investigated and the histologic appearance of the implant 46 days after implantation resembled that of normal spleen. The appearance of primitive myelopoietic stem in cells in the early phases of regeneration makes this an attractive model in which to study the biologic effects of tumour viruses.