Literature DB >> 1201247

Effects of ADP and ATP on bovine fibrinogen- and ristocetin-induced platelet aggregation in Glanzmann's thrombasthenia.

I Cohen, T Glaser, U Seligsohn.   

Abstract

With thrombasthenic platelets, aggregation induced by ristocetin (R) and bovine fibrinogen (BF) is reversible, provided ATP is not added to the system. ADP inhibits BF and R induced aggregation, and when added after the onset of aggregation causes rapid disaggregation. ATP prevents these inhibitory and disaggregation effects of ADP. A mechanism is suggested whereby co-operative effects occur between receptors in the membranes of thrombasthenic platelets.

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Year:  1975        PMID： 1201247     DOI： 10.1111/j.1365-2141.1975.tb00865.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  4 in total

1.  A murine monoclonal antibody that completely blocks the binding of fibrinogen to platelets produces a thrombasthenic-like state in normal platelets and binds to glycoproteins IIb and/or IIIa.

Authors:  B S Coller; E I Peerschke; L E Scudder; C A Sullivan
Journal:  J Clin Invest       Date:  1983-07       Impact factor: 14.808

2.  Functionally thrombasthenic state in normal platelets following the administration of ticlopidine.

Authors:  G Di Minno; A M Cerbone; P L Mattioli; S Turco; C Iovine; M Mancini
Journal:  J Clin Invest       Date:  1985-02       Impact factor: 14.808

3.  Platelet membrane defects in Glanzmann's thrombasthenia. Evidence for decreased amounts of two major glycoproteins.

Authors:  D R Phillips; P P Agin
Journal:  J Clin Invest       Date:  1977-09       Impact factor: 14.808

4.  Deletion of the platelet-specific alloantigen PlA1 from platelets in Glanzmann's thrombasthenia.

Authors:  T J Kunicki; R H Aster
Journal:  J Clin Invest       Date:  1978-05       Impact factor: 14.808
  4 in total

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