| Literature DB >> 12011292 |
F Bagnato1, C Pozzilli, C Scagnolari, F Bellomi, P Pasqualetti, C Gasperini, E Millefiorini, S Galgani, M Spadaro, G Antonelli.
Abstract
Interferon (IFN)-beta1a induction of neopterin and beta2-microglobulin (beta2-MG) were evaluated over 1 year in patients with MS. Neopterin and beta2-MG levels peaked 24 to 48 hours after weekly injections of IFNbeta1a over the entire study period. Predose levels of neopterin decreased significantly, consistent with a long-term decrease in IFNgamma expression and macrophage activation during IFNbeta-1a treatment. Predose levels of beta2-MG increased, the significance of which is as yet unclear.Entities:
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Year: 2002 PMID： 12011292 DOI： 10.1212/wnl.58.9.1409
Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910