Literature DB >> 12011031

Proteolysis of CD14 on human gingival fibroblasts by arginine-specific cysteine proteinases from Porphyromonas gingivalis leading to down-regulation of lipopolysaccharide-induced interleukin-8 production.

Hiroyuki Tada1, Shunji Sugawara, Eiji Nemoto, Nobuhiro Takahashi, Takahisa Imamura, Jan Potempa, James Travis, Hidetoshi Shimauchi, Haruhiko Takada.   

Abstract

Arginine-specific cysteine proteinases (gingipains-R) from periodontopathic Porphyromonas gingivalis cleaved CD14, a bacterial pattern recognition receptor, on human gingival fibroblasts (HGF). Consequently, gingipains-R reduced lipopolysaccharide-induced interleukin-8 production by HGF, indicating that gingipains-R inhibited CD14-dependent HGF activation and are involved in immune evasion by the bacterium in periodontal tissues.

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Year:  2002        PMID： 12011031      PMCID： PMC127988          DOI： 10.1128/IAI.70.6.3304-3307.2002

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  38 in total

1.  Activation of blood coagulation factor IX by gingipains R, arginine-specific cysteine proteinases from Porphyromonas gingivalis.

Authors:  T Imamura; S Tanase; T Hamamoto; J Potempa; J Travis
Journal:  Biochem J       Date:  2001-01-15       Impact factor: 3.857

2.  Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.

Authors:  O Takeuchi; K Hoshino; T Kawai; H Sanjo; H Takada; T Ogawa; K Takeda; S Akira
Journal:  Immunity       Date:  1999-10       Impact factor: 31.745

3.  Activation of human prothrombin by arginine-specific cysteine proteinases (Gingipains R) from porphyromonas gingivalis.

Authors:  T Imamura; A Banbula; P J Pereira; J Travis; J Potempa
Journal:  J Biol Chem       Date:  2001-03-16       Impact factor: 5.157

4.  Arginine-specific protease from Porphyromonas gingivalis activates protease-activated receptors on human oral epithelial cells and induces interleukin-6 secretion.

Authors:  A Lourbakos; J Potempa; J Travis; M R D'Andrea; P Andrade-Gordon; R Santulli; E J Mackie; R N Pike
Journal:  Infect Immun       Date:  2001-08       Impact factor: 3.441

5.  Cleavage of CD14 on human gingival fibroblasts cocultured with activated neutrophils is mediated by human leukocyte elastase resulting in down-regulation of lipopolysaccharide-induced IL-8 production.

Authors:  E Nemoto; S Sugawara; H Tada; H Takada; H Shimauchi; H Horiuchi
Journal:  J Immunol       Date:  2000-11-15       Impact factor: 5.422

6.  Comparison of pathogenic properties between two types of arginine-specific cysteine proteinases (gingipains-R) from Porphyromonas gingivalis.

Authors:  T Imamura; J Potempa; J Travis
Journal:  Microb Pathog       Date:  2000-09       Impact factor: 3.738

7.  Activation of protease-activated receptors by gingipains from Porphyromonas gingivalis leads to platelet aggregation: a new trait in microbial pathogenicity.

Authors:  A Lourbakos; Y P Yuan; A L Jenkins; J Travis; P Andrade-Gordon; R Santulli; J Potempa; R N Pike
Journal:  Blood       Date:  2001-06-15       Impact factor: 22.113

8.  Expression of myeloid differentiation antigens on normal and malignant myeloid cells.

Authors:  J D Griffin; J Ritz; L M Nadler; S F Schlossman
Journal:  J Clin Invest       Date:  1981-10       Impact factor: 14.808

9.  Antigens on human monocytes identified by monoclonal antibodies.

Authors:  R F Todd; L M Nadler; S F Schlossman
Journal:  J Immunol       Date:  1981-04       Impact factor: 5.422

10.  MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4.

Authors:  R Shimazu; S Akashi; H Ogata; Y Nagai; K Fukudome; K Miyake; M Kimoto
Journal:  J Exp Med       Date:  1999-06-07       Impact factor: 14.307
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  19 in total

1.  Inactivation of membrane tumor necrosis factor alpha by gingipains from Porphyromonas gingivalis.

Authors:  Renata Mezyk-Kopec; Malgorzata Bzowska; Jan Potempa; Monika Bzowska; Natalia Jura; Aneta Sroka; Roy A Black; Joanna Bereta
Journal:  Infect Immun       Date:  2005-03       Impact factor: 3.441

2.  Identification of a gingipain-sensitive surface ligand of Porphyromonas gingivalis that induces Toll-like receptor 2- and 4-independent NF-kappaB activation in CHO cells.

Authors:  Koki Haruyama; Atsutoshi Yoshimura; Mariko Naito; Mami Kishimoto; Mikio Shoji; Yoshimitsu Abiko; Yoshitaka Hara; Koji Nakayama
Journal:  Infect Immun       Date:  2009-08-10       Impact factor: 3.441

3.  Discrete proteolysis of focal contact and adherens junction components in Porphyromonas gingivalis-infected oral keratinocytes: a strategy for cell adhesion and migration disabling.

Authors:  Edith Hintermann; Susan Kinder Haake; Urs Christen; Andrew Sharabi; Vito Quaranta
Journal:  Infect Immun       Date:  2002-10       Impact factor: 3.441

4.  Cleavage of CD14 and LBP by a protease from Prevotella intermedia.

Authors:  James Deschner; Anuradha Singhal; Ping Long; Chau-Ching Liu; Nicholas Piesco; Sudha Agarwal
Journal:  Arch Microbiol       Date:  2003-05-01       Impact factor: 2.552

5.  In vitro models of tissue penetration and destruction by Porphyromonas gingivalis.

Authors:  Elisoa Andrian; Daniel Grenier; Mahmoud Rouabhia
Journal:  Infect Immun       Date:  2004-08       Impact factor: 3.441

6.  Porphyromonas gingivalis lipopolysaccharide antagonizes Escherichia coli lipopolysaccharide at toll-like receptor 4 in human endothelial cells.

Authors:  Stephen R Coats; Robert A Reife; Brian W Bainbridge; T Thu-Thao Pham; Richard P Darveau
Journal:  Infect Immun       Date:  2003-12       Impact factor: 3.441

Review 7.  Corruption of innate immunity by bacterial proteases.

Authors:  Jan Potempa; Robert N Pike
Journal:  J Innate Immun       Date:  2009       Impact factor: 7.349

8.  Lysine-specific gingipain promotes lipopolysaccharide- and active-vitamin D3-induced osteoclast differentiation by degrading osteoprotegerin.

Authors:  Rika Yasuhara; Yoichi Miyamoto; Masamichi Takami; Takahisa Imamura; Jan Potempa; Kentaro Yoshimura; Ryutaro Kamijo
Journal:  Biochem J       Date:  2009-04-01       Impact factor: 3.857

9.  Kinin danger signals proteolytically released by gingipain induce Fimbriae-specific IFN-gamma- and IL-17-producing T cells in mice infected intramucosally with Porphyromonas gingivalis.

Authors:  Ana Carolina Monteiro; Aline Scovino; Susane Raposo; Vinicius Mussa Gaze; Catia Cruz; Erik Svensjö; Marcelo Sampaio Narciso; Ana Paula Colombo; João B Pesquero; Eduardo Feres-Filho; Ky-Anh Nguyen; Aneta Sroka; Jan Potempa; Julio Scharfstein
Journal:  J Immunol       Date:  2009-08-17       Impact factor: 5.422

10.  Porphyromonas gingivalis gingipains selectively reduce CD14 expression, leading to macrophage hyporesponsiveness to bacterial infection.

Authors:  Asaf Wilensky; Rinat Tzach-Nahman; Lior Shapira; Gabriel Nussbaum; Jan Potempa
Journal:  J Innate Immun       Date:  2014-09-16       Impact factor: 7.349
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