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Literature DB >> 12011029

Role of gamma interferon in Helicobacter pylori induction of inflammatory mediators during murine infection.

Marygorret Obonyo¹, Donald G Guiney, Julia Harwood, Joshua Fierer, Sheri P Cole.

Abstract

Gamma interferon (IFN-gamma) has been proposed to play an important role in Helicobacter-related gastritis. Using the IFN-gamma gene knockout (IFN-gamma(-/-)) mouse model and a murine gastric epithelial cell line, GSM06, we demonstrated that Helicobacter pylori maximally induced macrophage inflammatory protein-2 (MIP-2) and inducible nitric oxide synthase (iNOS) mRNA only in wild-type mice. MIP-2 and iNOS mRNA were also induced by H. pylori in GSM06 cells. Induction of cyclooxygenase 2 mRNA through IFN-gamma was demonstrated in GSM06 cells. These data indicate that IFN-gamma mediates the induction of MIP-2 and iNOS mRNA expression by H. pylori in mice.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2002 PMID： 12011029 PMCID： PMC127973 DOI： 10.1128/IAI.70.6.3295-3299.2002

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

34 in total

1. Interferon gamma and interleukin 4 stimulate prolonged expression of inducible nitric oxide synthase in human airway epithelium through synthesis of soluble mediators.

Authors: F H Guo; K Uetani; S J Haque; B R Williams; R A Dweik; F B Thunnissen; W Calhoun; S C Erzurum
Journal: J Clin Invest Date: 1997-08-15 Impact factor: 14.808

2. Cyclooxygenase-2 expression in gastric antral mucosa before and after eradication of Helicobacter pylori infection.

Authors: C J McCarthy; L J Crofford; J Greenson; J M Scheiman
Journal: Am J Gastroenterol Date: 1999-05 Impact factor: 10.864

3. Regulation of prostaglandin biosynthesis by nitric oxide is revealed by targeted deletion of inducible nitric-oxide synthase.

Authors: L J Marnett; T L Wright; B C Crews; S R Tannenbaum; J D Morrow
Journal: J Biol Chem Date: 2000-05-05 Impact factor: 5.157

4. A standardized mouse model of Helicobacter pylori infection: introducing the Sydney strain.

Authors: A Lee; J O'Rourke; M C De Ungria; B Robertson; G Daskalopoulos; M F Dixon
Journal: Gastroenterology Date: 1997-04 Impact factor: 22.682

5. Regulation of gastric epithelial cell growth by Helicobacter pylori: offdence for a major role of apoptosis.

Authors: S Wagner; W Beil; J Westermann; R P Logan; C T Bock; C Trautwein; J S Bleck; M P Manns
Journal: Gastroenterology Date: 1997-12 Impact factor: 22.682

6. Neutrophil activation by Helicobacter pylori.

Authors: C Mooney; J Keenan; D Munster; I Wilson; R Allardyce; P Bagshaw; B Chapman; V Chadwick
Journal: Gut Date: 1991-08 Impact factor: 23.059

7. Helicobacter pylori secretes a chemotactic factor for monocytes and neutrophils.

Authors: P M Craig; M C Territo; W E Karnes; J H Walsh
Journal: Gut Date: 1992-08 Impact factor: 23.059

8. Chemokines in the gastric mucosa in Helicobacter pylori infection.

Authors: Y Yamaoka; M Kita; T Kodama; N Sawai; T Tanahashi; K Kashima; J Imanishi
Journal: Gut Date: 1998-05 Impact factor: 23.059

Review 9. Prostaglandin endoperoxide synthase: why two isoforms?

Authors: C S Williams; R N DuBois
Journal: Am J Physiol Date: 1996-03

10. Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues.

Authors: P Tekamp-Olson; C Gallegos; D Bauer; J McClain; B Sherry; M Fabre; S van Deventer; A Cerami
Journal: J Exp Med Date: 1990-09-01 Impact factor: 14.307

21 in total

1. Gastric Sonic Hedgehog acts as a macrophage chemoattractant during the immune response to Helicobacter pylori.

Authors: Michael A Schumacher; Jessica M Donnelly; Amy C Engevik; Chang Xiao; Li Yang; Susan Kenny; Andrea Varro; Frédéric Hollande; Linda C Samuelson; Yana Zavros
Journal: Gastroenterology Date: 2012-01-25 Impact factor: 22.682

2. Anti-inflammatory activity of bone morphogenetic protein signaling pathways in stomachs of mice.

Authors: Hidehiko Takabayashi; Masahiko Shinohara; Maria Mao; Piangwarin Phaosawasdi; Mohamad El-Zaatari; Min Zhang; Tuo Ji; Kathryn A Eaton; Duyen Dang; John Kao; Andrea Todisco
Journal: Gastroenterology Date: 2014-04-18 Impact factor: 22.682

Review 3. Helicobacter pylori persistence: an overview of interactions between H. pylori and host immune defenses.

Authors: Holly M Scott Algood; Timothy L Cover
Journal: Clin Microbiol Rev Date: 2006-10 Impact factor: 26.132

4. Effects of myeloid differentiation primary response gene 88 (MyD88) activation on Helicobacter infection in vivo and induction of a Th17 response.

Authors: Marygorret Obonyo; Barry Rickman; Donald G Guiney
Journal: Helicobacter Date: 2011-10 Impact factor: 5.753

5. Lactobacillus johnsonii La1 attenuates Helicobacter pylori-associated gastritis and reduces levels of proinflammatory chemokines in C57BL/6 mice.

Authors: Dionyssios N Sgouras; Effrosini G Panayotopoulou; Beatriz Martinez-Gonzalez; Kalliopi Petraki; Spyros Michopoulos; Andreas Mentis
Journal: Clin Diagn Lab Immunol Date: 2005-12

6. Helicobacter pylori disrupts STAT1-mediated gamma interferon-induced signal transduction in epithelial cells.

Authors: David J Mitchell; Hien Q Huynh; Peter J M Ceponis; Nicola L Jones; Philip M Sherman
Journal: Infect Immun Date: 2004-01 Impact factor: 3.441

7. Accelerated progression of gastritis to dysplasia in the pyloric antrum of TFF2 -/- C57BL6 x Sv129 Helicobacter pylori-infected mice.

Authors: James G Fox; Arlin B Rogers; Mark T Whary; Zhongming Ge; Masa Ohtani; Evelyn Kurt Jones; Timothy C Wang
Journal: Am J Pathol Date: 2007-11 Impact factor: 4.307