Literature DB >> 12010516

Isolation and characterization of a novel postsynaptic/cytotoxic neurotoxin from Daboia russelli russelli venom.

R R J Shelke1, S Sathish, T V Gowda.   

Abstract

A postsynaptic neurotoxin was purified from Daboia russelli russelli venom using gel filtration, ion-exchange chromatography and reverse-phase high-performance liquid chromatography. The N-terminal sequence, molecular mass and pharmacological activities of the neurotoxin/cytotoxin indicate that it is a short-chain neurotoxin like that found in Elapid venom. This is the first report on the presence of such a postsynaptic neurotoxin from D. r. russelli venom.

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Year:  2002        PMID: 12010516     DOI: 10.1034/j.1399-3011.2002.02969.x

Source DB:  PubMed          Journal:  J Pept Res        ISSN: 1397-002X


  7 in total

1.  Lachesis muta (Viperidae) cDNAs reveal diverging pit viper molecules and scaffolds typical of cobra (Elapidae) venoms: implications for snake toxin repertoire evolution.

Authors:  Inácio L M Junqueira-de-Azevedo; Ana T C Ching; Eneas Carvalho; Fernanda Faria; Milton Y Nishiyama; Paulo L Ho; Marcelo R V Diniz
Journal:  Genetics       Date:  2006-04-02       Impact factor: 4.562

2.  Novel genes encoding six kinds of three-finger toxins in Ophiophagus hannah (king cobra) and function characterization of two recombinant long-chain neurotoxins.

Authors:  Jing Li; Huayuan Zhang; Jing Liu; Kangsen Xu
Journal:  Biochem J       Date:  2006-09-01       Impact factor: 3.857

3.  Neurotoxicity in Sri Lankan Russell's Viper (Daboia russelii) Envenoming is Primarily due to U1-viperitoxin-Dr1a, a Pre-Synaptic Neurotoxin.

Authors:  Anjana Silva; Sanjaya Kuruppu; Iekhsan Othman; Robert J A Goode; Wayne C Hodgson; Geoffrey K Isbister
Journal:  Neurotox Res       Date:  2016-07-11       Impact factor: 3.911

Review 4.  A Review and Database of Snake Venom Proteomes.

Authors:  Theo Tasoulis; Geoffrey K Isbister
Journal:  Toxins (Basel)       Date:  2017-09-18       Impact factor: 4.546

5.  Clinico-epidemiology and management of Russell's viper (Daboia russelii) envenoming in dogs in Sri Lanka.

Authors:  Ranjith B Adhikari; Indika B Gawarammana; D D N De Silva; Ashoka Dangolla; Chandima Mallawa; A D Premarathna; Indira D Silva
Journal:  Toxicol Rep       Date:  2019-08-07

6.  Biogeographic venom variation in Russell's viper (Daboia russelii) and the preclinical inefficacy of antivenom therapy in snakebite hotspots.

Authors:  R R Senji Laxme; Suyog Khochare; Saurabh Attarde; Vivek Suranse; Ashwin Iyer; Nicholas R Casewell; Romulus Whitaker; Gerard Martin; Kartik Sunagar
Journal:  PLoS Negl Trop Dis       Date:  2021-03-25

Review 7.  Neurotoxicity in snakebite--the limits of our knowledge.

Authors:  Udaya K Ranawaka; David G Lalloo; H Janaka de Silva
Journal:  PLoS Negl Trop Dis       Date:  2013-10-10
  7 in total

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