OBJECTIVE: To retrospectively analyse the secretor status in women with acute uncomplicated pyelonephritis, as non-secretors of histo-blood group antigens are reportedly at risk of recurrent urinary tract infections (UTIs). PATIENTS AND METHODS: The study included 245 women who had been diagnosed as having acute uncomplicated pyelonephritis in affiliated hospitals over the past 5 years. All women were sent antiseptic swabs, to collect saliva, and a questionnaire to survey their past UTI episodes and menstrual status. Responses with written informed consent were obtained from 106 women (median age 50.5 years, range 17-85). The secretor status was determined using the haemagglutination inhibition assay from the saliva on the swabs. RESULTS: Forty-four (41%) of the women were non-secretors, a significantly higher frequency than in the (control) Japanese population (217 of 960, 22.6%; P< 0.001). The incidence of non-secretors was significantly higher (P < 0.01) in premenopausal (26 of 46, 57%) than in postmenopausal women (18 of 60, 30%). CONCLUSION: These results suggest that non-secretor status is associated with a genetic susceptibility to acute uncomplicated pyelonephritis, especially in premenopausal women.
OBJECTIVE: To retrospectively analyse the secretor status in women with acute uncomplicated pyelonephritis, as non-secretors of histo-blood group antigens are reportedly at risk of recurrent urinary tract infections (UTIs). PATIENTS AND METHODS: The study included 245 women who had been diagnosed as having acute uncomplicated pyelonephritis in affiliated hospitals over the past 5 years. All women were sent antiseptic swabs, to collect saliva, and a questionnaire to survey their past UTI episodes and menstrual status. Responses with written informed consent were obtained from 106 women (median age 50.5 years, range 17-85). The secretor status was determined using the haemagglutination inhibition assay from the saliva on the swabs. RESULTS: Forty-four (41%) of the women were non-secretors, a significantly higher frequency than in the (control) Japanese population (217 of 960, 22.6%; P< 0.001). The incidence of non-secretors was significantly higher (P < 0.01) in premenopausal (26 of 46, 57%) than in postmenopausal women (18 of 60, 30%). CONCLUSION: These results suggest that non-secretor status is associated with a genetic susceptibility to acute uncomplicated pyelonephritis, especially in premenopausal women.
Authors: Alex Smithson; Ana Muñoz; Belen Suarez; Sara Maria Soto; Rafael Perello; Alex Soriano; Jose Antonio Martinez; Jordi Vila; Juan Pablo Horcajada; Jose Mensa; Francisco Lozano Journal: Clin Vaccine Immunol Date: 2007-01-03
Authors: Delia Scholes; Thomas R Hawn; Pacita L Roberts; Sue S Li; Ann E Stapleton; Lue-Ping Zhao; Walter E Stamm; Thomas M Hooton Journal: J Urol Date: 2010-06-19 Impact factor: 7.450
Authors: Jacinta Serpa; Nuno Mendes; Celso A Reis; Luis F Santos Silva; Raquel Almeida; Jacques Le Pendu; Leonor David Journal: Biochem J Date: 2004-11-01 Impact factor: 3.857
Authors: Luca Maroni; Stan F J van de Graaf; Simon D Hohenester; Ronald P J Oude Elferink; Ulrich Beuers Journal: Clin Rev Allergy Immunol Date: 2015-06 Impact factor: 8.667
Authors: Thomas R Hawn; Delia Scholes; Hongwei Wang; Sue S Li; Ann E Stapleton; Marta Janer; Alan Aderem; Walter E Stamm; Lue Ping Zhao; Thomas M Hooton Journal: PLoS One Date: 2009-12-15 Impact factor: 3.240