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Literature DB >> 1201006

Effect of 3-mercaptopicolinic acid on gluconeogenesis and gluconeogenic metabolite concentrations in the isolated perfused rat liver.

Abstract

3-Mercaptopicolinic acid inhibited gluconeogenesis from lactate and alanine, but not dihydroxyacetone, in the perfused rat liver. Hepatic metabolite concentrations suggested that gluconeogenesis was inhibited at phosphoenolpyruvate carboxykinase. The compound is very effective at low concentrations, and seems an ideal agent for use in studying metabolic regulation involving gluconeogenesis and anaplerotic mechanisms.

Entities: Chemical Species

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Year: 1975 PMID： 1201006 PMCID： PMC1165714 DOI： 10.1042/bj1500137

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

6 in total

1. Alteration of rat liver phosphoenolpyruvate carboxykinase activity by L-tryptophan in vivo and metals in vitro.

Authors: D O Foster; H A Lardy; P D Ray; J B Johnston
Journal: Biochemistry Date: 1967-07 Impact factor: 3.162

2. Influence of L-tryptophan and its metabolites on gluconeogenesis in the isolated, perfused liver.

Authors: C M Veneziale; P Walter; N Kneer; H A Lardy
Journal: Biochemistry Date: 1967-07 Impact factor: 3.162

3. The regulation of gluconeogenesis. The effect of pent-4-enoic acid on gluconeogenesis and on the gluconeogenic metabolite concentrations of isolated perfused rat liver.

Authors: C J Toews; C Lowy; N B Ruderman
Journal: J Biol Chem Date: 1970-02-25 Impact factor: 5.157

4. Influence of fluorocarbon emulsions on hepatic metabolism in perfused rat liver.

Authors: M N Goodman; R Parrilla; C J Toews
Journal: Am J Physiol Date: 1973-12

5. Paths of carbon in gluconeogenesis and lipogenesis. IV. Inhibition by L-tryptophan of hepatic gluconeogenesis at the level of phosphoenolpyruvate formation.

Authors: P D Ray; D O Foster; H A Lardy
Journal: J Biol Chem Date: 1966-09-10 Impact factor: 5.157

6. 3-mercaptopicolinic acid, an inhibitor of gluconeogenesis.

Authors: N W DiTullio; C E Berkoff; B Blank; V Kostos; E J Stack; H L Saunders
Journal: Biochem J Date: 1974-03 Impact factor: 3.857

6 in total

9 in total

1. Altered mitochondrial function and metabolic inflexibility associated with loss of caveolin-1.

Authors: Ingrid Wernstedt Asterholm; Dorothy I Mundy; Jian Weng; Richard G W Anderson; Philipp E Scherer
Journal: Cell Metab Date: 2012-02-08 Impact factor: 27.287

2. Hyperglycaemic activity and metabolic effects of 3-aminopicolinic acid.

Authors: M J MacDonald; M T Huang; H A Lardy
Journal: Biochem J Date: 1978-11-15 Impact factor: 3.857

3. Prolone metabolism in isolated rat liver cells.

Authors: H E Hensgens; A J Meijer; J R Williamson; J A Gimpel; J M Tager
Journal: Biochem J Date: 1978-03-15 Impact factor: 3.857

4. The contribution of pyruvate cycling to loss of [6-3H]glucose during conversion of glucose to glycogen in hepatocytes: effects of insulin, glucose and acinar origin of hepatocytes.

Authors: L Agius; D Tosh; M Peak
Journal: Biochem J Date: 1993-01-01 Impact factor: 3.857

8. Stimulation of [1-14C]oleate oxidation to 14CO2 in isolated rat hepatocytes by the catecholamines, vasopressin and angiotensin. A possible mechanism of action.

Authors: M C Sugden; D I Watts
Journal: Biochem J Date: 1983-04-15 Impact factor: 3.857

9. Glycogen synthesis in amphibian oocytes: evidence for an indirect pathway.

Authors: E Kessi; V Guixé; A Preller; T Ureta
Journal: Biochem J Date: 1996-04-15 Impact factor: 3.857