PURPOSE: To investigate late radiation effects on hearing, vestibular function, and taste after conventional radiotherapy in brain tumor patients. METHODS AND MATERIALS: Hearing, vestibular function, and taste were assessed in 33 brain tumor patients irradiated unilaterally to the tumor-bearing hemisphere and the temporal bone. Median observation time after completion of radiotherapy was 13 years; the fraction dose was 1.8 Gy, and mean radiation dose was 53.1 Gy. RESULTS: Deep ulceration in the external ear canal and osteoradionecrosis on the irradiated side was seen in three patients. Reduced hearing was found for air and bone conduction of the irradiated side compared to the opposite side (0.25-2 kHz: 6.1 dB, 4 kHz: 10.3 dB, 6 kHz: 15.6 dB, and 8 kHz: 16.5 dB). For bone conduction, the corresponding figures were 0.25-2 kHz: 5.5 dB and 4 kHz: 8.2 dB. Three patients had a canal paresis of the irradiated side, and three patients had affection of the chorda tympani. CONCLUSION: Irradiation of the temporal bone with doses usually given in the treatment of patients with brain tumors may cause osteoradionecrosis, sensorineural hearing loss, dysfunction of the vestibular inner ear, and loss of taste. Head-and-neck examination should be included in the follow-up of long-term survivors.
PURPOSE: To investigate late radiation effects on hearing, vestibular function, and taste after conventional radiotherapy in brain tumorpatients. METHODS AND MATERIALS: Hearing, vestibular function, and taste were assessed in 33 brain tumorpatients irradiated unilaterally to the tumor-bearing hemisphere and the temporal bone. Median observation time after completion of radiotherapy was 13 years; the fraction dose was 1.8 Gy, and mean radiation dose was 53.1 Gy. RESULTS: Deep ulceration in the external ear canal and osteoradionecrosis on the irradiated side was seen in three patients. Reduced hearing was found for air and bone conduction of the irradiated side compared to the opposite side (0.25-2 kHz: 6.1 dB, 4 kHz: 10.3 dB, 6 kHz: 15.6 dB, and 8 kHz: 16.5 dB). For bone conduction, the corresponding figures were 0.25-2 kHz: 5.5 dB and 4 kHz: 8.2 dB. Three patients had a canal paresis of the irradiated side, and three patients had affection of the chorda tympani. CONCLUSION: Irradiation of the temporal bone with doses usually given in the treatment of patients with brain tumors may cause osteoradionecrosis, sensorineural hearing loss, dysfunction of the vestibular inner ear, and loss of taste. Head-and-neck examination should be included in the follow-up of long-term survivors.
Authors: Barbara A Jereczek-Fossa; Elena Rondi; Andrzej Zarowski; Alberto D'Onofrio; Daniela Alterio; Mario Ciocca; Livia Corinna Bianchi; Marco Krengli; Luca Calabrese; Mohssen Ansarin; Gioacchino Giugliano; Roberto Orecchia Journal: Strahlenther Onkol Date: 2011-05-16 Impact factor: 3.621
Authors: C Marc Leyrer; Michael D Chan; Ann M Peiffer; Elizabeth Horne; Michelle Harmon; Annette F Carter; William H Hinson; Susan Mirlohi; Susan E Duncan; Andrea M Dietrich; Glenn J Lesser Journal: Pract Radiat Oncol Date: 2013-07-25
Authors: Christopher M Nutting; James P Morden; Matthew Beasley; Shreerang Bhide; Audrey Cook; Emma De Winton; Marie Emson; Mererid Evans; Lydia Fresco; Simon Gollins; Dorothy Gujral; Kevin Harrington; Mano Joseph; Catherine Lemon; Linda Luxon; Qurrat van den Blink; Ruheena Mendes; Aisha Miah; Kate Newbold; Robin Prestwich; Martin Robinson; Paul Sanghera; Joanna Simpson; Muthiah Sivaramalingam; Narayanan Nair Srihari; Mark Sydenham; Emma Wells; Stephanie Witts; Emma Hall Journal: Eur J Cancer Date: 2018-10-01 Impact factor: 9.162