Randomized clinical trials of combined estrogen-androgen preparations: effects on sexual functioning.

OBJECTIVE: To review the randomized controlled trials of the efficacy of combined estrogen-androgen (E-A) preparations on sexual functioning in postmenopausal women. PATIENT(S): Naturally and surgically menopausal women. MAIN OUTCOME MEASURE(S): Changes in aspects of sexual functioning. RESULT(S): In general, a high degree of agreement exists among the findings of these well-controlled trials that combined E-A preparations enhance psychological well-being as well as sexual desire and interest and, sometimes, increases the frequency of sexual intercourse and orgasm compared with estrogen-alone treatment in both naturally and surgically postmenopausal women. CONCLUSION(S): In selected cases, combined E-A therapy can enhance the quality of life for both naturally and surgically postmenopausal women.