BACKGROUND: In 1999 Cardno et al reported that long CAG repeats in the calcium-activated potassium channel gene hSKCa3/KCNN3 are associated with higher negative symptom dimension scores in schizophrenia patients. There has been no attempt to replicate the results. In this study, we investigated whether a symptom polymorphism of schizophrenia is associated with both the CAG repeat numbers and the difference in allele sizes. METHODS: We tested the association of CAG repeats with symptom models of schizophrenia in 117 unrelated Jewish patients. A multivariate analysis (MANOVA) of two models of schizophrenia with the repeat distribution and the difference in allele sizes was performed. RESULTS: We found a significant positive association of the number of CAG repeats with negative syndrome, anergia, activation, and paranoid symptoms. In addition, nonparanoid schizophrenia patients who had differences in allele sizes were characterized by earlier onset of illness. CONCLUSIONS: The study supports the hypothesis that the combined effect of long CAG repeats and the differences in allele sizes contribute to symptom expression of schizophrenia, particularly on the anergia-activation-paranoid axis.
BACKGROUND: In 1999 Cardno et al reported that long CAG repeats in the calcium-activated potassium channel gene hSKCa3/KCNN3 are associated with higher negative symptom dimension scores in schizophreniapatients. There has been no attempt to replicate the results. In this study, we investigated whether a symptom polymorphism of schizophrenia is associated with both the CAG repeat numbers and the difference in allele sizes. METHODS: We tested the association of CAG repeats with symptom models of schizophrenia in 117 unrelated Jewish patients. A multivariate analysis (MANOVA) of two models of schizophrenia with the repeat distribution and the difference in allele sizes was performed. RESULTS: We found a significant positive association of the number of CAG repeats with negative syndrome, anergia, activation, and paranoid symptoms. In addition, nonparanoid schizophreniapatients who had differences in allele sizes were characterized by earlier onset of illness. CONCLUSIONS: The study supports the hypothesis that the combined effect of long CAG repeats and the differences in allele sizes contribute to symptom expression of schizophrenia, particularly on the anergia-activation-paranoid axis.
Authors: Sabrina Grube; Martin F Gerchen; Bartosz Adamcio; Luis A Pardo; Sabine Martin; Dörthe Malzahn; Sergi Papiol; Martin Begemann; Katja Ribbe; Heidi Friedrichs; Konstantin A Radyushkin; Michael Müller; Fritz Benseler; Joachim Riggert; Peter Falkai; Heike Bickeböller; Klaus-Armin Nave; Nils Brose; Walter Stühmer; Hannelore Ehrenreich Journal: EMBO Mol Med Date: 2011-03-24 Impact factor: 12.137
Authors: David López Herráez; Marc Bauchet; Kun Tang; Christoph Theunert; Irina Pugach; Jing Li; Madhusudan R Nandineni; Arnd Gross; Markus Scholz; Mark Stoneking Journal: PLoS One Date: 2009-11-18 Impact factor: 3.240