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Literature DB >> 12007434

MAP kinase module: the Ksr connection.

Abstract

Ksr has been genetically defined as a component of the Ras/MAP kinase pathway, but its role has been unclear. New studies now provide evidence that Ksr is important for signal transmission within the MAP kinase module, where it apparently acts as a location-regulated scaffold connecting MEK to Raf.

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Year: 2002 PMID： 12007434 DOI： 10.1016/s0960-9822(02)00831-x

Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834

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Cited

13 in total

1. Bimodal regulation of RAF by CNK in Drosophila.

Authors: Mélanie Douziech; François Roy; Gino Laberge; Martin Lefrançois; Anne-Valérie Armengod; Marc Therrien
Journal: EMBO J Date: 2003-10-01 Impact factor: 11.598

2. Drosophila Raf's N terminus contains a novel conserved region and can contribute to torso RTK signaling.

Authors: Jian Ding; Oren Tchaicheeyan; Linda Ambrosio
Journal: Genetics Date: 2009-12-14 Impact factor: 4.562

3. KSR1 and EPHB4 Regulate Myc and PGC1β To Promote Survival of Human Colon Tumors.

Authors: Jamie L McCall; Drew Gehring; Beth K Clymer; Kurt W Fisher; Binita Das; David L Kelly; Hyunseok Kim; Michael A White; Robert E Lewis
Journal: Mol Cell Biol Date: 2016-08-12 Impact factor: 4.272

4. Induction of kinase suppressor of RAS-1(KSR-1) gene by 1, alpha25-dihydroxyvitamin D3 in human leukemia HL60 cells through a vitamin D response element in the 5'-flanking region.

Authors: X Wang; T-T Wang; J H White; G P Studzinski
Journal: Oncogene Date: 2006-05-29 Impact factor: 9.867

5. Expression of human kinase suppressor of Ras 2 (hKSR-2) gene in HL60 leukemia cells is directly upregulated by 1,25-dihydroxyvitamin D(3) and is required for optimal cell differentiation.

Authors: Xuening Wang; Tian-Tian Wang; John H White; George P Studzinski
Journal: Exp Cell Res Date: 2007-05-31 Impact factor: 3.905

MAP kinase module: the Ksr connection.

1. Bimodal regulation of RAF by CNK in Drosophila.

2. Drosophila Raf's N terminus contains a novel conserved region and can contribute to torso RTK signaling.

3. KSR1 and EPHB4 Regulate Myc and PGC1β To Promote Survival of Human Colon Tumors.

4. Induction of kinase suppressor of RAS-1(KSR-1) gene by 1, alpha25-dihydroxyvitamin D3 in human leukemia HL60 cells through a vitamin D response element in the 5'-flanking region.

5. Expression of human kinase suppressor of Ras 2 (hKSR-2) gene in HL60 leukemia cells is directly upregulated by 1,25-dihydroxyvitamin D(3) and is required for optimal cell differentiation.

6. hKSR-2, a vitamin D-regulated gene, inhibits apoptosis in arabinocytosine-treated HL60 leukemia cells.

Review 7. Change or die: targeting adaptive signaling to kinase inhibition in cancer cells.

8. Genome-wide analysis and experimentation of plant serine/ threonine/tyrosine-specific protein kinases.

9. Aurora-A overexpression enhances cell-aggregation of Ha-ras transformants through the MEK/ERK signaling pathway.

10. Mitogen-Activated Protein (MAP) Kinase Scaffolding Proteins: A Recount.