| Literature DB >> 12007431 |
Abstract
Attachment of sister chromatids to microtubules from opposite spindle poles--bi-orientation--generates tension at the kinetochores. The Ipl1/Aurora B kinase responds to the absence of tension at mono-oriented chromosomes and promotes microtubule turnover and spindle checkpoint activation until a stable bi-oriented attachment is achieved.Entities:
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Year: 2002 PMID： 12007431 DOI： 10.1016/s0960-9822(02)00828-x
Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834