Literature DB >> 12007401

Spliceosomal snRNAs: Mg(2+)-dependent chemistry at the catalytic core?

Tommaso Villa1, Jeffrey A Pleiss, Christine Guthrie.   

Abstract

Since the discovery of self-splicing RNAs, it has been suspected that the snRNAs are the catalytic components of the spliceosome. Recent evidence supports both the catalytic potential of the spliceosomal snRNAs and their resemblance to elements of group II introns.

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Year:  2002        PMID： 12007401     DOI： 10.1016/s0092-8674(02)00726-2

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  33 in total

1.  Modification of Sm small nuclear RNAs occurs in the nucleoplasmic Cajal body following import from the cytoplasm.

Authors:  Beáta E Jády; Xavier Darzacq; Karen E Tucker; A Gregory Matera; Edouard Bertrand; Tamás Kiss
Journal:  EMBO J       Date:  2003-04-15       Impact factor: 11.598

2.  Characterization of the catalytic activity of U2 and U6 snRNAs.

Authors:  Saba Valadkhan; James L Manley
Journal:  RNA       Date:  2003-07       Impact factor: 4.942

3.  Group II intron splicing factors derived by diversification of an ancient RNA-binding domain.

Authors:  Gerard J Ostheimer; Rosalind Williams-Carrier; Susan Belcher; Erin Osborne; Jennifer Gierke; Alice Barkan
Journal:  EMBO J       Date:  2003-08-01       Impact factor: 11.598

4.  Multiple functions for the invariant AGC triad of U6 snRNA.

Authors:  Angela K Hilliker; Jonathan P Staley
Journal:  RNA       Date:  2004-06       Impact factor: 4.942

5.  Identification and analysis of U5 snRNA variants in Drosophila.

Authors:  Li Chen; Dennis J Lullo; Enbo Ma; Susan E Celniker; Donald C Rio; Jennifer A Doudna
Journal:  RNA       Date:  2005-10       Impact factor: 4.942

6.  Structure of a self-splicing group II intron catalytic effector domain 5: parallels with spliceosomal U6 RNA.

Authors:  Mahadevan Seetharaman; Nadukkudy V Eldho; Richard A Padgett; Kwaku T Dayie
Journal:  RNA       Date:  2006-02       Impact factor: 4.942

7.  Proximity of conserved U6 and U2 snRNA elements to the 5' splice site region in activated spliceosomes.

Authors:  Britta M Rhode; Klaus Hartmuth; Eric Westhof; Reinhard Lührmann
Journal:  EMBO J       Date:  2006-05-11       Impact factor: 11.598

8.  Three essential and conserved regions of the group II intron are proximal to the 5'-splice site.

Authors:  Alexandre de Lencastre; Anna Marie Pyle
Journal:  RNA       Date:  2007-11-26       Impact factor: 4.942

Review 9.  The expanding transcriptome: the genome as the 'Book of Sand'.

Authors:  Luis M Mendes Soares; Juan Valcárcel
Journal:  EMBO J       Date:  2006-03-02       Impact factor: 11.598

10.  RNAtomy of the Spliceosome's heart.

Authors:  Sophie Bonnal; Juan Valcárcel
Journal:  EMBO J       Date:  2013-09-24       Impact factor: 11.598
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