Literature DB >> 1200714

Degradation of deoxyribonucleic acid by guinea pig epidermal extracts.

T Miyagawa, M Anai, H Urabe.   

Abstract

The capability of guinea pig epidermal extracts to hydrolyze deoxyribonucleic acid has been studied. The results of investigation by gel filtration on Sephadex G-75 column and by viscometry on the mode of hydrolysis of deoxyribonucleic acid by epidermal extracts revealed that deoxyribonucleic acid was degraded by both endonuclease and exonuclease activities. The exhaustive digestion by epidermal extracts yielded the complete degradation of deoxyribonucleic acid to mononucleosides or further metabolites. The enzyme systems involved in the deoxyribonucleic acid degradation include at least an endonuclease, an exonuclease and a phosphatase.

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Year:  1975        PMID： 1200714     DOI： 10.1007/bf00561538

Source DB:  PubMed          Journal:  Arch Dermatol Res            Impact factor:   3.017


  11 in total

1.  STUDIES ON THE BIOCHEMISTRY OF EPIDERMIS. II. SOME CHARACTERISTICS OF DEOXYRIBONUCLEASES I AND II OF ALBINO GUINEA PIG EPIDERMIS AND SALINE EXTRACTS OF HAIR.

Authors:  J TABACHNICK
Journal:  J Invest Dermatol       Date:  1964-06       Impact factor: 8.551

2.  HISTOCHEMICAL STUDIES ON THE SKIN. I. THE ACTIVITY OF PHOSPHATASES DURING THE HISTOGENESIS OF THE SKIN IN THE RAT.

Authors:  K HASHIMOTO; K OGAWA
Journal:  Am J Anat       Date:  1963-07

3.  The localization of ribonuclease and deoxyribonuclease activities in normal and psoriatic epidermis.

Authors:  G K STEIGLEDER; W P RAAB
Journal:  J Invest Dermatol       Date:  1962-04       Impact factor: 8.551

4.  Nucleic acid-splitting enzymes in human epidermis and their possible role in keratinization.

Authors:  P SANTOIANNI; S ROTHMAN
Journal:  J Invest Dermatol       Date:  1961-12       Impact factor: 8.551

5.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

6.  Studies on the biochemistry of epidermis. 3. Content and some characteristics of 5'-nucleotidases, pyrophosphatases and phosphomonoesterases of albino guinea pig and rat epidermis.

Authors:  J Tabachnick; J S Perlish
Journal:  J Invest Dermatol       Date:  1967-06       Impact factor: 8.551

7.  Isolation and properties of a phosphodiesterase from newborn mouse skin.

Authors:  F Zaruba; M A Karasek; E M Farber
Journal:  J Invest Dermatol       Date:  1967-11       Impact factor: 8.551

8.  Separation of nucleosides on polyacrylamide gel columns.

Authors:  M Carrara; G Bernardi
Journal:  Biochim Biophys Acta       Date:  1968-01-29

9.  The biochemical property and physiologic significance of deoxyribonuclease in the epidermis. I. Partial purification and properties of DNase isolated from cow snout epidermis.

Authors:  T Miyagawa; R M Ogura
Journal:  J Invest Dermatol       Date:  1971-11       Impact factor: 8.551

10.  Purine and pyrimidine metabolism in human epidermis.

Authors:  J De Bersaques
Journal:  J Invest Dermatol       Date:  1967-02       Impact factor: 8.551
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  2 in total

1.  Nuclear differentiation and ultimate fate during epidermal keratinization. Two-wavelength and cytofluorometric DNA investigations completed by computerized scanning image analysis.

Authors:  D Broekaert; P Van Oostveldt; P Coucke; J De Bersaques; E Gillis; P Reyniers
Journal:  Arch Dermatol Res       Date:  1986       Impact factor: 3.017

2.  Endogenous endonuclease-induced DNA fragmentation: an early event in cell-mediated cytolysis.

Authors:  R C Duke; R Chervenak; J J Cohen
Journal:  Proc Natl Acad Sci U S A       Date:  1983-10       Impact factor: 11.205
  2 in total

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