BACKGROUND: This study was done to determine variables associated with infectious rhabdomyolysis (IRM). METHODS: In this retrospective case-control study, rhabdomyolysis (RM) was defined as a fivefold or greater elevation in creatine kinase (CK) levels with a muscle/brain (MB) fraction <5%. Patients with myocardial infarction or cerebrovascular accident or a recent history of surgery, trauma, or immobilization were excluded. RESULTS: We analyzed 52 cases of RM seen at our institution between 1992 and 2000; IRM was the most frequent cause (31%), most commonly respiratory tract infections (38%). When a microorganism could be identified (50%), it was more often gram-negative (63%). Patients with IRM were elderly and had fever and lower CK levels. Infectious rhabdomyolysis was associated with a higher morbidity but not with a higher risk of death. CONCLUSIONS: Infectious rhabdomyolysis is the main cause of RM and must be suspected in elderly patients with fever and low levels of CK.
BACKGROUND: This study was done to determine variables associated with infectious rhabdomyolysis (IRM). METHODS: In this retrospective case-control study, rhabdomyolysis (RM) was defined as a fivefold or greater elevation in creatine kinase (CK) levels with a muscle/brain (MB) fraction <5%. Patients with myocardial infarction or cerebrovascular accident or a recent history of surgery, trauma, or immobilization were excluded. RESULTS: We analyzed 52 cases of RM seen at our institution between 1992 and 2000; IRM was the most frequent cause (31%), most commonly respiratory tract infections (38%). When a microorganism could be identified (50%), it was more often gram-negative (63%). Patients with IRM were elderly and had fever and lower CK levels. Infectious rhabdomyolysis was associated with a higher morbidity but not with a higher risk of death. CONCLUSIONS:Infectious rhabdomyolysis is the main cause of RM and must be suspected in elderly patients with fever and low levels of CK.
Authors: A Dugué; H Bagheri; M Lapeyre-Mestre; J F Tournamille; L Sailler; G Dedieu; R Salvayre; J P Thouvenot; P Massip; J L Montastruc Journal: Eur J Clin Pharmacol Date: 2004-04-28 Impact factor: 2.953
Authors: Matthew P Cheng; Michael G Kozoriz; Amir A Ahmadi; John Kelsall; Katryn Paquette; Jake M Onrot Journal: Allergy Asthma Clin Immunol Date: 2016-02-11 Impact factor: 3.406
Authors: Abbe N Vallejo; Henry J Mroczkowski; Joshua J Michel; Michael Woolford; Harry C Blair; Patricia Griffin; Elizabeth McCracken; Stephanie J Mihalik; Miguel Reyes-Mugica; Jerry Vockley Journal: Clin Transl Immunology Date: 2021-06-27