| Literature DB >> 12003986 |
Katsunori Yanagihara1, Kazunori Tomono, Yoshifumi Imamura, Yukihiro Kaneko, Misuzu Kuroki, Toyomitsu Sawai, Yoshitsugu Miyazaki, Yoichi Hirakata, Hiroshi Mukae, Jun-Ichi Kadota, Shigeru Kohno.
Abstract
Fourteen-membered macrolides (e.g. clarithromycin and erythromycin), but not 16-membered macrolides (e.g. josamycin), are effective in diffuse panbronchiolitis. However, there are no studies that have compared the effects of 14- and 16-membered macrolide antibiotics on biofilm formation. Treatment with high-dose clarithromycin (100 mg/kg) resulted in a significant decrease in the number of viable bacteria in an experimental murine model. Josamycin at a dose of up to 100 mg/kg had no effect on the number of viable bacteria in the lung. Our results may explain, at least in part, the clinical efficacy of 14-membered macrolide antibiotics in patients with chronic pneumonia caused by Pseudomonas aeruginosa.Entities:
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Year: 2002 PMID： 12003986 DOI： 10.1093/jac/dkf013
Source DB: PubMed Journal: J Antimicrob Chemother ISSN： 0305-7453 Impact factor: 5.790