| Literature DB >> 12003529 |
Xiao-Ting Huang1, Qing-Yun Chen.
Abstract
Ethyl alpha-fluoro silyl enol ether is stereoselectively synthesized in high yield from inexpensive chlorofluoroacetate and Mg (or Zn) in DMF (or HMPA). Lewis acid promoted aldol reaction of this enol ether with aldehydes and ketones gives alpha-fluoro-beta-hydroxy esters in good to excellent yields.Entities:
Year: 2002 PMID： 12003529 DOI： 10.1021/jo010820+
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354