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Literature DB >> 1200031

Linkage data on MN and the Hb beta locus.

Abstract

A sample of 28 informative families was studied for linkage between Hb beta and MN. Values of the neuterized recombination fraction from these and other families from the literature excluded a recombination fraction of less than .30 between these loci. Our results support different recombination values for males and females (theta equals .34 abd .50, respectively). A simple approach to estimate the sample size required as well as a study of the relationship between sibship size and sample size under conditions of loose linkage are also presented.

Entities: Gene

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Year: 1975 PMID： 1200031 PMCID： PMC1762910

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

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References

14 in total

1. Sequential tests for the detection of linkage.

Authors: N E MORTON
Journal: Am J Hum Genet Date: 1955-09 Impact factor: 11.025

2. Linkage tests of Mediterranean anemia with blood groups, blood types, Rh factors and eye color.

Authors: I LUDWIN; D LIMENTANI; W DAMESHEK
Journal: Am J Hum Genet Date: 1952-09 Impact factor: 11.025

3. Absence of linkage between the genes responsible for the sickling phenomenon, the MN blood types, and the S-agglutinogen.

Authors: J V NEEL; W J SCHULL; H S SHAPIRO
Journal: Am J Hum Genet Date: 1952-09 Impact factor: 11.025

Linkage data on MN and the Hb beta locus.

1. Sequential tests for the detection of linkage.

2. Linkage tests of Mediterranean anemia with blood groups, blood types, Rh factors and eye color.

3. Absence of linkage between the genes responsible for the sickling phenomenon, the MN blood types, and the S-agglutinogen.

4. Linkage Between the Genes for Sickle Cells and the M-N Blood Types.

5. Chromosomal localization of human haemoglobin structural genes.

6. Linkage between the MN- and Hb beta-loci?

7. MN blood-group locus: data concerning the possible chromosomal location.

8. Genetic linkage analysis of human hemoglobin variants.

9. Autoradiographic studies of human chromosomes. II. Data concerning the position of the MN locus.

10. Mapping human autosomes: assignment of the MN locus to a specific segment in the long arm of chromosome no. 2.